(Des-Histidine1) (Nϵ-phenylthiocarbamoyllysine12)-glucagon: Effects on glycogenolysis in perfused rat liver

B. A. Khan, Marvin D. Bregman, C. A. Nugent, Victor J. Hruby, K. Brendel

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

(Des-Histidine1) (Nε{lunate}-phenylthiocarbamoyllysine12)-glucagon, synthesized by the one-step Edman degradation procedure is a competitive inhibitor of glucagon action in the rat liver plasma membrane adenylate cyclase system. However, in the perfused rat liver, the compound did not inhibit glucagon stimulated glycogenolysis even when used at a concentration 100-fold in excess of native glucagon. Instead, it showed a weak potency, but full agonist activity, stimulating liver glycogenolysis to 100% of the level obtained by glucagon. These results are discussed in terms of the possible mechanism(s) of glucagon action.

Original languageEnglish (US)
Pages (from-to)729-736
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume93
Issue number3
DOIs
StatePublished - Apr 14 1980

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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