Descriptive and risk factor analysis of nonsyndromic sacral agenesis

National Birth Defects Prevention Study, 1997–2011

for the National Birth Defects Prevention Study

Research output: Contribution to journalArticle

Abstract

Sacral agenesis is a rare birth defect characterized by partial or complete absence of the sacrum. We sought to (a) describe case characteristics, (b) estimate birth prevalence, and (c) identify risk factors for nonsyndromic sacral agenesis using data from the National Birth Defects Prevention Study (NBDPS). The NBDPS was a population-based, case–control study involving pregnancies with estimated dates of delivery from October 1997 through December 2011. We estimated birth prevalence using all NBDPS eligible cases. Using self-reported maternal exposure information, we conducted multivariable logistic regression analysis to identify potential risk factors overall and among women without diabetes. The birth prevalence of sacral agenesis was 2.6/100,000 live births. In the multivariable analysis, multifetal pregnancy, pre-existing Type 1 diabetes, and pre-existing Type 2 diabetes were positively and significantly associated with sacral agenesis, albeit estimates were imprecise. Preexisting Type 1 diabetes was the strongest risk factor (adjusted odds ratio = 96.6, 95% confidence interval = 43.5–214.7). Among women without diabetes, periconceptional smoking was positively and significantly associated with sacral agenesis. Our findings underscore the importance of smoking cessation programs among women planning pregnancy and the importance of better understanding the role of glycemic control before and during pregnancy when designing interventions for primary prevention of sacral agenesis.

Original languageEnglish (US)
JournalAmerican Journal of Medical Genetics, Part A
DOIs
StatePublished - Jan 1 2019

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Statistical Factor Analysis
Pregnancy
Parturition
Type 1 Diabetes Mellitus
Maternal Exposure
Sacrum
Live Birth
Smoking Cessation
Primary Prevention
Type 2 Diabetes Mellitus
Sacral defect and anterior sacral meningocele
Logistic Models
Smoking
Odds Ratio
Regression Analysis
Confidence Intervals
Population

Keywords

  • birth defect
  • birth prevalence
  • diabetes
  • sacral agenesis

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Descriptive and risk factor analysis of nonsyndromic sacral agenesis : National Birth Defects Prevention Study, 1997–2011. / for the National Birth Defects Prevention Study.

In: American Journal of Medical Genetics, Part A, 01.01.2019.

Research output: Contribution to journalArticle

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