Desensitization of neurokinin A receptors expressed by B82 fibroblasts

Alden K. Henderson, William R Roeske, Thomas L. Smith, Henry I. Yamamura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK2 receptor. Desensitized cells also showed decreased Ca2+ mobilization. While NK2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.

Original languageEnglish (US)
Pages (from-to)75-78
Number of pages4
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume245
Issue number1
DOIs
StatePublished - Mar 15 1993

Fingerprint

Neurokinin-2 Receptors
Inositol
Fibroblasts
Neurokinin A
Substance P
Stomach
Complementary DNA

Keywords

  • Desensitization
  • Neurokinin A
  • NK receptors

ASJC Scopus subject areas

  • Pharmacology

Cite this

Desensitization of neurokinin A receptors expressed by B82 fibroblasts. / Henderson, Alden K.; Roeske, William R; Smith, Thomas L.; Yamamura, Henry I.

In: European Journal of Pharmacology: Molecular Pharmacology, Vol. 245, No. 1, 15.03.1993, p. 75-78.

Research output: Contribution to journalArticle

Henderson, Alden K. ; Roeske, William R ; Smith, Thomas L. ; Yamamura, Henry I. / Desensitization of neurokinin A receptors expressed by B82 fibroblasts. In: European Journal of Pharmacology: Molecular Pharmacology. 1993 ; Vol. 245, No. 1. pp. 75-78.
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