Desensitization of neurokinin A receptors expressed by B82 fibroblasts

Alden K. Henderson, William R. Roeske, Thomas L. Smith, Henry I. Yamamura

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

After chronic exposure to neurokinin A, a time-dependent and recoverable desensitization of inositol monophosphate accumulation occurred in B82 fibroblasts transfected with cDNAs encoding for the bovine stomach NK2 receptor. Desensitized cells also showed decreased Ca2+ mobilization. While NK2 receptor antagonists had no effect on inositol monophosphate accumulation, substance P and senktide both produced a small degree of desensitization.

Original languageEnglish (US)
Pages (from-to)75-78
Number of pages4
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume245
Issue number1
DOIs
StatePublished - Mar 15 1993

Keywords

  • Desensitization
  • NK receptors
  • Neurokinin A

ASJC Scopus subject areas

  • Pharmacology

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