Design and optimization of pulsed Chemical Exchange Saturation Transfer MRI using a multiobjective genetic algorithm

Eriko S. Yoshimaru, Edward A. Randtke, Mark "Marty" Pagel, Julio Cárdenas-Rodríguez

Research output: Contribution to journalArticle

6 Scopus citations


Pulsed Chemical Exchange Saturation Transfer (CEST) MRI experimental parameters and RF saturation pulse shapes were optimized using a multiobjective genetic algorithm. The optimization was carried out for RF saturation duty cycles of 50% and 90%, and results were compared to continuous wave saturation and Gaussian waveform. In both simulation and phantom experiments, continuous wave saturation performed the best, followed by parameters and shapes optimized by the genetic algorithm and then followed by Gaussian waveform. We have successfully demonstrated that the genetic algorithm is able to optimize pulse CEST parameters and that the results are translatable to clinical scanners.

Original languageEnglish (US)
JournalJournal of Magnetic Resonance
StateAccepted/In press - Feb 26 2015



  • Chemical Exchange Saturation Transfer
  • Genetic algorithm
  • Iopromide
  • Pulse design
  • Pulsed CEST MRI
  • Salicylic acid
  • Shaped pulses

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Biochemistry
  • Biophysics
  • Condensed Matter Physics

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