Design and utilization of macrophage and vascular smooth muscle cell co-culture systems in atherosclerotic cardiovascular disease investigation

Mary C. Zuniga, Sharla L.Powell White, Wei Zhou

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Atherosclerotic cardiovascular disease has been acknowledged as a chronic inflammatory condition. Monocytes and macrophages lead the inflammatory pathology of atherosclerosis whereas changes in atheromatous plaque thickness and matrix composition are attributed to vascular smooth muscle cells. Because these cell types are key players in atherosclerosis progression, it is crucial to utilize a reliable system to investigate their interaction. In vitro co-culture systems are useful platforms to study specific molecular mechanisms between cells. This review aims to summarize the various co-culture models that have been developed to investigate vascular smooth muscle cell and monocyte/macrophage interactions, focusing on the monocyte/macrophage effects on vascular smooth muscle cell function.

Original languageEnglish (US)
Pages (from-to)394-406
Number of pages13
JournalVascular Medicine (United Kingdom)
Volume19
Issue number5
DOIs
StatePublished - Oct 11 2014
Externally publishedYes

Keywords

  • Atherosclerosis
  • co-culture
  • inflammation
  • macrophage
  • smooth muscle cell

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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