Design Effect of Metallic (Durable) and Polymeric (Resorbable) Stents on Blood Flow and Platelet Activation

Gil Marom, Senthil K. Eswaran, Richard J. Rapoza, Syed F.A. Hossainy, Marvin J Slepian, Danny Bluestein

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bioresorbable vascular scaffolds (BVS) provide transient vessel support for occluded coronary arteries while resorbing over time, potentially allowing vessel restoration approximating the native, healthy state. Clinical trials indicate that the Absorb BVS (Abbott Vascular, Santa Clara, CA) performance was similar to that of the Xience metallic drug-eluting stent (DES), with low long-term complications rates. However, when under-deployed in very small vessels (diameter < 2.25 mm), the thrombosis rate of BVS was higher, possibly due to the effect of strut thickness on the hemodynamics (157 μm BVS vs. 81 μm DES). This study aims to determine the influence of BVS design in vessels of varying diameter on the potential platelet activation. Sixteen computational fluid dynamics models of vessels of varying diameter (1.8–3.0 mm), strut thickness (81–157 μm), and BVS/DES designs were compared. Platelet stress accumulation (SA), a metric for the activation potential, was calculated along platelet flow trajectories and their probability distribution was compared. The models were consistent with clinical observations, indicating that devices deployed in very small vessels exhibited increased probability for platelet activity as compared to the same devices deployed in nominal sized vessels. Deployment, although with residual stenosis, increased probability for higher SA than in similar diameter straight vessels. Reducing BVS struts thickness while maintaining their pattern improved performance closer to that of DES. Our findings highlight the importance of appropriate vessel sizing and deployment technique for BVS, and may help designing future BVS with thinner struts, ultimately improving performance in very small vessels.

Original languageEnglish (US)
JournalArtificial Organs
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Stents
Platelet Activation
Platelets
Scaffolds
Blood Vessels
Blood
Blood Platelets
Chemical activation
Struts
Drug-Eluting Stents
Pharmaceutical Preparations
Hemodynamics
Equipment and Supplies
Probability distributions
Restoration
Dynamic models
Hydrodynamics
Computational fluid dynamics
Trajectories
Coronary Vessels

Keywords

  • Bioresorbable scaffolds
  • Computational fluid dynamics
  • Coronary stents
  • Thrombogenicity

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Design Effect of Metallic (Durable) and Polymeric (Resorbable) Stents on Blood Flow and Platelet Activation. / Marom, Gil; Eswaran, Senthil K.; Rapoza, Richard J.; Hossainy, Syed F.A.; Slepian, Marvin J; Bluestein, Danny.

In: Artificial Organs, 01.01.2018.

Research output: Contribution to journalArticle

Marom, Gil ; Eswaran, Senthil K. ; Rapoza, Richard J. ; Hossainy, Syed F.A. ; Slepian, Marvin J ; Bluestein, Danny. / Design Effect of Metallic (Durable) and Polymeric (Resorbable) Stents on Blood Flow and Platelet Activation. In: Artificial Organs. 2018.
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