Design, manufacturing, and opto-mechanical considerations for multimodal micro-endoscope featuring optical coherence microscopy, multiphoton microscopy, and visible navigation

David Vega, Gabriella Romano, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Complex endoscopes which utilize optics with less than 1.5 mm diameter have an elevated risk of failure. Therefore, to ensure functionality and minimize risk proper design, optomechanical analysis and modelling must be performed while taking into consideration current manufacturing capabilities. Our endoscope is designed to perform Optical Coherence and Multiphoton Microscopy (OCM and MPM) which are powerful endoscopic imaging techniques used to characterize tissue. Separately each imaging technique has limitations when used by itself; however, this design combines these two modalities into a single optical system to work in synergy achieving both high sensitivity and specificity for diagnosis at the point of care. The optical design features two optical paths with different numerical apertures (NA) through a single lens system with a scanning optical fiber. The dual path is achieved using dichroic coatings embedded in a triplet that functions in a telescope like fashion. A high NA ∼0.44 path is designed to perform OCM and MPM while a low NA ∼.18 path is designed for the visible spectrum to allow navigation of the endoscope to areas of interest. We present the optical design of the endoscope, optomechanical considerations, manufacturability, stress and temperature effects. All these factors may be a source of problems in such small optics utilizing rare materials such as ZnS MS lenses. While very tight tolerances were the driving factor for the manufacturability of this system, temperature and stress must also be evaluated to obtain a better idea of the durability of the endoscope at the point of care. While it is challenging to evaluate the real performance of multimodality endoscopes, the models ensure that the system is designed for the expected imaging techniques, providing acceptable imaging across the entire field of view. Finally, we will give insight on what lessons were learned during the design, analysis, lens manufacturing, and assembling processes of the endoscope to provide a baseline of parameters to take into consideration when designing such complex small optical systems.

Original languageEnglish (US)
Title of host publicationOptical Design and Engineering VII
EditorsAndrew P. Wood, Rolf Wartmann, Laurent Mazuray
PublisherSPIE
Volume10690
ISBN (Print)9781510619173
DOIs
StatePublished - Jan 1 2018
EventOptical Design and Engineering VII 2018 - Frankfurt, Germany
Duration: May 14 2018May 17 2018

Other

OtherOptical Design and Engineering VII 2018
CountryGermany
CityFrankfurt
Period5/14/185/17/18

Fingerprint

Multiphoton Microscopy
Endoscope
endoscopes
Endoscopy
navigation
Microscopy
Navigation
Microscopic examination
manufacturing
Manufacturing
microscopy
numerical aperture
Imaging
imaging techniques
Lens
Imaging techniques
Lenses
design analysis
Path
Optical design

Keywords

  • micro-endoscope
  • micro-optics
  • microscopy
  • multimodal endoscopy
  • optical design
  • optical models
  • optomechanical design

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Design, manufacturing, and opto-mechanical considerations for multimodal micro-endoscope featuring optical coherence microscopy, multiphoton microscopy, and visible navigation. / Vega, David; Romano, Gabriella; Barton, Jennifer K.

Optical Design and Engineering VII. ed. / Andrew P. Wood; Rolf Wartmann; Laurent Mazuray. Vol. 10690 SPIE, 2018. 1069012.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Vega, D, Romano, G & Barton, JK 2018, Design, manufacturing, and opto-mechanical considerations for multimodal micro-endoscope featuring optical coherence microscopy, multiphoton microscopy, and visible navigation. in AP Wood, R Wartmann & L Mazuray (eds), Optical Design and Engineering VII. vol. 10690, 1069012, SPIE, Optical Design and Engineering VII 2018, Frankfurt, Germany, 5/14/18. https://doi.org/10.1117/12.2312691
Vega, David ; Romano, Gabriella ; Barton, Jennifer K. / Design, manufacturing, and opto-mechanical considerations for multimodal micro-endoscope featuring optical coherence microscopy, multiphoton microscopy, and visible navigation. Optical Design and Engineering VII. editor / Andrew P. Wood ; Rolf Wartmann ; Laurent Mazuray. Vol. 10690 SPIE, 2018.
@inproceedings{3569a156d7dd46d5accc3790e8c489c5,
title = "Design, manufacturing, and opto-mechanical considerations for multimodal micro-endoscope featuring optical coherence microscopy, multiphoton microscopy, and visible navigation",
abstract = "Complex endoscopes which utilize optics with less than 1.5 mm diameter have an elevated risk of failure. Therefore, to ensure functionality and minimize risk proper design, optomechanical analysis and modelling must be performed while taking into consideration current manufacturing capabilities. Our endoscope is designed to perform Optical Coherence and Multiphoton Microscopy (OCM and MPM) which are powerful endoscopic imaging techniques used to characterize tissue. Separately each imaging technique has limitations when used by itself; however, this design combines these two modalities into a single optical system to work in synergy achieving both high sensitivity and specificity for diagnosis at the point of care. The optical design features two optical paths with different numerical apertures (NA) through a single lens system with a scanning optical fiber. The dual path is achieved using dichroic coatings embedded in a triplet that functions in a telescope like fashion. A high NA ∼0.44 path is designed to perform OCM and MPM while a low NA ∼.18 path is designed for the visible spectrum to allow navigation of the endoscope to areas of interest. We present the optical design of the endoscope, optomechanical considerations, manufacturability, stress and temperature effects. All these factors may be a source of problems in such small optics utilizing rare materials such as ZnS MS lenses. While very tight tolerances were the driving factor for the manufacturability of this system, temperature and stress must also be evaluated to obtain a better idea of the durability of the endoscope at the point of care. While it is challenging to evaluate the real performance of multimodality endoscopes, the models ensure that the system is designed for the expected imaging techniques, providing acceptable imaging across the entire field of view. Finally, we will give insight on what lessons were learned during the design, analysis, lens manufacturing, and assembling processes of the endoscope to provide a baseline of parameters to take into consideration when designing such complex small optical systems.",
keywords = "micro-endoscope, micro-optics, microscopy, multimodal endoscopy, optical design, optical models, optomechanical design",
author = "David Vega and Gabriella Romano and Barton, {Jennifer K}",
year = "2018",
month = "1",
day = "1",
doi = "10.1117/12.2312691",
language = "English (US)",
isbn = "9781510619173",
volume = "10690",
editor = "Wood, {Andrew P.} and Rolf Wartmann and Laurent Mazuray",
booktitle = "Optical Design and Engineering VII",
publisher = "SPIE",

}

TY - GEN

T1 - Design, manufacturing, and opto-mechanical considerations for multimodal micro-endoscope featuring optical coherence microscopy, multiphoton microscopy, and visible navigation

AU - Vega, David

AU - Romano, Gabriella

AU - Barton, Jennifer K

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Complex endoscopes which utilize optics with less than 1.5 mm diameter have an elevated risk of failure. Therefore, to ensure functionality and minimize risk proper design, optomechanical analysis and modelling must be performed while taking into consideration current manufacturing capabilities. Our endoscope is designed to perform Optical Coherence and Multiphoton Microscopy (OCM and MPM) which are powerful endoscopic imaging techniques used to characterize tissue. Separately each imaging technique has limitations when used by itself; however, this design combines these two modalities into a single optical system to work in synergy achieving both high sensitivity and specificity for diagnosis at the point of care. The optical design features two optical paths with different numerical apertures (NA) through a single lens system with a scanning optical fiber. The dual path is achieved using dichroic coatings embedded in a triplet that functions in a telescope like fashion. A high NA ∼0.44 path is designed to perform OCM and MPM while a low NA ∼.18 path is designed for the visible spectrum to allow navigation of the endoscope to areas of interest. We present the optical design of the endoscope, optomechanical considerations, manufacturability, stress and temperature effects. All these factors may be a source of problems in such small optics utilizing rare materials such as ZnS MS lenses. While very tight tolerances were the driving factor for the manufacturability of this system, temperature and stress must also be evaluated to obtain a better idea of the durability of the endoscope at the point of care. While it is challenging to evaluate the real performance of multimodality endoscopes, the models ensure that the system is designed for the expected imaging techniques, providing acceptable imaging across the entire field of view. Finally, we will give insight on what lessons were learned during the design, analysis, lens manufacturing, and assembling processes of the endoscope to provide a baseline of parameters to take into consideration when designing such complex small optical systems.

AB - Complex endoscopes which utilize optics with less than 1.5 mm diameter have an elevated risk of failure. Therefore, to ensure functionality and minimize risk proper design, optomechanical analysis and modelling must be performed while taking into consideration current manufacturing capabilities. Our endoscope is designed to perform Optical Coherence and Multiphoton Microscopy (OCM and MPM) which are powerful endoscopic imaging techniques used to characterize tissue. Separately each imaging technique has limitations when used by itself; however, this design combines these two modalities into a single optical system to work in synergy achieving both high sensitivity and specificity for diagnosis at the point of care. The optical design features two optical paths with different numerical apertures (NA) through a single lens system with a scanning optical fiber. The dual path is achieved using dichroic coatings embedded in a triplet that functions in a telescope like fashion. A high NA ∼0.44 path is designed to perform OCM and MPM while a low NA ∼.18 path is designed for the visible spectrum to allow navigation of the endoscope to areas of interest. We present the optical design of the endoscope, optomechanical considerations, manufacturability, stress and temperature effects. All these factors may be a source of problems in such small optics utilizing rare materials such as ZnS MS lenses. While very tight tolerances were the driving factor for the manufacturability of this system, temperature and stress must also be evaluated to obtain a better idea of the durability of the endoscope at the point of care. While it is challenging to evaluate the real performance of multimodality endoscopes, the models ensure that the system is designed for the expected imaging techniques, providing acceptable imaging across the entire field of view. Finally, we will give insight on what lessons were learned during the design, analysis, lens manufacturing, and assembling processes of the endoscope to provide a baseline of parameters to take into consideration when designing such complex small optical systems.

KW - micro-endoscope

KW - micro-optics

KW - microscopy

KW - multimodal endoscopy

KW - optical design

KW - optical models

KW - optomechanical design

UR - http://www.scopus.com/inward/record.url?scp=85052860452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052860452&partnerID=8YFLogxK

U2 - 10.1117/12.2312691

DO - 10.1117/12.2312691

M3 - Conference contribution

AN - SCOPUS:85052860452

SN - 9781510619173

VL - 10690

BT - Optical Design and Engineering VII

A2 - Wood, Andrew P.

A2 - Wartmann, Rolf

A2 - Mazuray, Laurent

PB - SPIE

ER -