Design of a multi-modality salpingoscope for visualization of the ovary and oviducts

Jennifer K. Barton, Gabriella Romano, David Vega, Kelli C. Kiekens, Harrison T. Thurgood, Dominique B. Galvez, Orkhongua Batjargal, Yi Hsin Ou, Khanh Kieu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent discoveries suggest that ovarian cancer has its origins in the oviducts (Fallopian tubes) and may exist as intraepithelial carcinoma for up to 6 years. One route of access to the oviducts and ovaries is through the wall of the vagina. We have developed an approximately 3.8 mm diameter rigid salpingoscope for surveillance of high-risk women and early detection of ovarian cancer. The salpingoscope contains multiple advanced imaging modalities, as well as a channel for instillation of saline or dyes, and another channel for introduction of biopsy forceps. The single optical channel combines the modalities of multispectral fluorescence and reflectance wide-field imaging, multiphoton microscopy (MPM), and optical coherence tomography (OCT). Multiple modalities through a single channel are achieved by a novel lens system with dichroic coatings which create separate optical paths for visible wavelengths (low numerical aperture (NA) imaging) and near-infrared wavelengths (high NA imaging). A quartered piezoelectric tube actuator scans a dual-clad fiber with added mass to facilitate both relatively slow (OCT) and fast (wide field and MPM) scanning. Visible wavelength laser diodes are the source for wide field reflectance and fluorescence imaging, with remitted light collected through 12 high NA multimode fibers. A novel femtosecond laser with near-infrared output provides the source for OCT and MPM, with remitted light collected through the core and inner cladding of the dual-clad fiber, respectively. Detectors include high sensitivity photodiodes for wide field, a linear array with spectrometer for OCT, and photomultiplier tubes to collect twoand three-photon signals for MPM imaging.

Original languageEnglish (US)
Title of host publicationClinical and Preclinical Optical Diagnostics II
EditorsJ. Quincy Brown, Ton G. van Leeuwen
PublisherSPIE
ISBN (Electronic)9781510628397
DOIs
StatePublished - Jan 1 2019
EventClinical and Preclinical Optical Diagnostics II 2019 - Munich, Germany
Duration: Jun 23 2019Jun 25 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11073
ISSN (Print)1605-7422

Conference

ConferenceClinical and Preclinical Optical Diagnostics II 2019
CountryGermany
CityMunich
Period6/23/196/25/19

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Keywords

  • Endoscopy
  • Fluorescence Imaging
  • Multiphoton Imaging
  • Natural Orifice
  • Optical Coherence Tomography
  • Ovarian Cancer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Barton, J. K., Romano, G., Vega, D., Kiekens, K. C., Thurgood, H. T., Galvez, D. B., Batjargal, O., Ou, Y. H., & Kieu, K. (2019). Design of a multi-modality salpingoscope for visualization of the ovary and oviducts. In J. Q. Brown, & T. G. van Leeuwen (Eds.), Clinical and Preclinical Optical Diagnostics II [1107307] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073). SPIE. https://doi.org/10.1117/12.2526768