Design of an everting balloon to deploy a microendoscope to the fallopian tubes

Molly Keenan, Caitlin Howard, Tyler Tate, Ian McGuiness, Alexis Sauer-Budge, John Black, Urs Utzinger, Jennifer K. Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The 5-year survival rate for ovarian cancer is only 45% largely due to lack of effective screening methods. Current methods include palpation, transvaginal ultrasound, and the CA-125 blood test. Finding disease reliably and at an early stage increase survival to 92%. We have designed and built a 0.7 mm endoscope for the early detection of ovarian cancer. Inserted transvaginally through the working channel of a hysteroscope, the falloposcope creates a minimally invasive procedure for the screening of high risk women. To improve the ease-of-use and safety of falloposcope deployment, we are working to create an everting balloon. Currently, the falloposcope would require a skilled user to operate due to the challenging anatomy of the fallopian tubes - a small opening from the uterus (< 1 mm), tortuous path, and delicate lumenal features. A balloon delivery system would gently open the fallopian tube and guide the falloposcope down the center of lumen. We show balloon design and discuss integration with the falloposcope prototype. We test possible mechanical damage to the tissue due to scraping, puncture, or overstretching. Successful introduction of the everting balloon to simplify falloposcope delivery could expand screening beyond specialized centers to smaller clinical locations.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics XII
EditorsAndreas Mandelis, Bernard Choi, Brian J. F. Wong, Justus F. Ilgner, Laura Marcu, Melissa C. Skala, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Guillermo J. Tearney, Kenton W. Gregory, Paul J. Campagnola
PublisherSPIE
ISBN (Electronic)9781628419245
DOIs
StatePublished - 2016
EventPhotonic Therapeutics and Diagnostics XII - San Francisco, United States
Duration: Feb 13 2016Feb 14 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9689
ISSN (Print)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics XII
CountryUnited States
CitySan Francisco
Period2/13/162/14/16

Keywords

  • burst testing
  • efficacy
  • introducer sheath
  • pressure
  • safety
  • screening test

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Keenan, M., Howard, C., Tate, T., McGuiness, I., Sauer-Budge, A., Black, J., Utzinger, U., & Barton, J. K. (2016). Design of an everting balloon to deploy a microendoscope to the fallopian tubes. In A. Mandelis, B. Choi, B. J. F. Wong, J. F. Ilgner, L. Marcu, M. C. Skala, N. Kollias, H. Zeng, H. W. Kang, G. J. Tearney, K. W. Gregory, & P. J. Campagnola (Eds.), Photonic Therapeutics and Diagnostics XII [968944] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9689). SPIE. https://doi.org/10.1117/12.2213345