Design of an in-vivo multi-spectral confocal microendoscope for clinical trials

Andrew R Rouse, Anthony A. Tanbakuchi, Joshua A. Udovich, Arthur F Gmitro

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

We previously reported on the development and testing of a multi-spectral confocal microendoscope. Here we present a new system that will be used during an early stage clinical trial. The new microendoscope is significantly smaller, uses fewer optical elements, and is structurally more robust. The slit-scanning confocal system employs two synchronized single-axes scan mirrors and an externally coupled imaging catheter with automated focus control and dye delivery systems. In grayscale collection mode the confocal microendoscope operates at 30 frames-per-second with 3μm lateral resolution and 25μm axial resolution. The multi-spectral collection mode operates at 0.5 frames-per-second when acquiring 32 spectral channels with an average minimum resolvable wavelength difference of 12nm. The system will be used, in grayscale mode, to image ovaries during a small scale clinical trial on women undergoing oophorectomy. Recent grayscale and multi-spectral imaging results from ex-vivo human tissues are presented.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume6082
DOIs
StatePublished - 2006
EventEndoscopic Microscopy - San Jose, CA, United States
Duration: Jan 22 2006Jan 22 2006

Other

OtherEndoscopic Microscopy
CountryUnited States
CitySan Jose, CA
Period1/22/061/22/06

Fingerprint

Imaging techniques
Catheters
Optical devices
ovaries
Dyes
Tissue
Scanning
Wavelength
slits
delivery
Testing
dyes
mirrors
scanning
wavelengths

Keywords

  • Confocal
  • Endoscope
  • Fiber
  • Fluorescence
  • Microscopy
  • Optics
  • Spectral
  • Spectroscopy
  • Tissue

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Rouse, A. R., Tanbakuchi, A. A., Udovich, J. A., & Gmitro, A. F. (2006). Design of an in-vivo multi-spectral confocal microendoscope for clinical trials. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 6082). [608205] https://doi.org/10.1117/12.646913

Design of an in-vivo multi-spectral confocal microendoscope for clinical trials. / Rouse, Andrew R; Tanbakuchi, Anthony A.; Udovich, Joshua A.; Gmitro, Arthur F.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 6082 2006. 608205.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rouse, AR, Tanbakuchi, AA, Udovich, JA & Gmitro, AF 2006, Design of an in-vivo multi-spectral confocal microendoscope for clinical trials. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 6082, 608205, Endoscopic Microscopy, San Jose, CA, United States, 1/22/06. https://doi.org/10.1117/12.646913
Rouse AR, Tanbakuchi AA, Udovich JA, Gmitro AF. Design of an in-vivo multi-spectral confocal microendoscope for clinical trials. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 6082. 2006. 608205 https://doi.org/10.1117/12.646913
Rouse, Andrew R ; Tanbakuchi, Anthony A. ; Udovich, Joshua A. ; Gmitro, Arthur F. / Design of an in-vivo multi-spectral confocal microendoscope for clinical trials. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 6082 2006.
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