Design of an in-vivo multi-spectral confocal microendoscope for clinical trials

Andrew R. Rouse, Anthony A. Tanbakuchi, Joshua A. Udovich, Arthur F. Gmitro

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

We previously reported on the development and testing of a multi-spectral confocal microendoscope. Here we present a new system that will be used during an early stage clinical trial. The new microendoscope is significantly smaller, uses fewer optical elements, and is structurally more robust. The slit-scanning confocal system employs two synchronized single-axes scan mirrors and an externally coupled imaging catheter with automated focus control and dye delivery systems. In grayscale collection mode the confocal microendoscope operates at 30 frames-per-second with 3μm lateral resolution and 25μm axial resolution. The multi-spectral collection mode operates at 0.5 frames-per-second when acquiring 32 spectral channels with an average minimum resolvable wavelength difference of 12nm. The system will be used, in grayscale mode, to image ovaries during a small scale clinical trial on women undergoing oophorectomy. Recent grayscale and multi-spectral imaging results from ex-vivo human tissues are presented.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
DOIs
StatePublished - May 8 2006
EventEndoscopic Microscopy - San Jose, CA, United States
Duration: Jan 22 2006Jan 22 2006

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6082
ISSN (Print)0277-786X

Other

OtherEndoscopic Microscopy
CountryUnited States
CitySan Jose, CA
Period1/22/061/22/06

Keywords

  • Confocal
  • Endoscope
  • Fiber
  • Fluorescence
  • Microscopy
  • Optics
  • Spectral
  • Spectroscopy
  • Tissue

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Rouse, A. R., Tanbakuchi, A. A., Udovich, J. A., & Gmitro, A. F. (2006). Design of an in-vivo multi-spectral confocal microendoscope for clinical trials. In Proceedings of SPIE - The International Society for Optical Engineering [608205] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6082). https://doi.org/10.1117/12.646913