Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors

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8 Citations (Scopus)

Abstract

Design of biologically active peptides is of critical importance for the development of potent, selective, nontoxic bioavailable drugs. A major approach that has been developed to accomplish this is the development of methods for the design and synthesis of a wide variety of cyclic peptides and peptidomimetics. In this short and general review, we outline the methods that have been developed for cyclization of peptides and how these have been used for peptide and peptidomimetic design using the melanotropin peptides and melanocortin receptors MC1R, MC3R, MC4R, and MC5R to illustrate aspects of this approach.

Original languageEnglish (US)
Pages (from-to)884-888
Number of pages5
JournalBiopolymers
Volume106
Issue number6
DOIs
StatePublished - Nov 1 2016

Fingerprint

Melanocortin Receptors
Cyclic Peptides
Bioactivity
Modulators
Peptides
Peptidomimetics
Melanocyte-Stimulating Hormones
Peptide Receptors
Cyclization
Pharmaceutical Preparations

Keywords

  • conformational constraints
  • cyclic peptides
  • peptide design

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

Cite this

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AB - Design of biologically active peptides is of critical importance for the development of potent, selective, nontoxic bioavailable drugs. A major approach that has been developed to accomplish this is the development of methods for the design and synthesis of a wide variety of cyclic peptides and peptidomimetics. In this short and general review, we outline the methods that have been developed for cyclization of peptides and how these have been used for peptide and peptidomimetic design using the melanotropin peptides and melanocortin receptors MC1R, MC3R, MC4R, and MC5R to illustrate aspects of this approach.

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