Design, synthesis, and validation of a branched flexible linker for bioactive peptides

Martina E. Bowen, Yasunari Monguchi, Rajesh Sankaranarayanan, Josef Vagner, Lucinda J. Begay, Liping Xu, Bhumasamudram Jagadish, Victor J Hruby, Robert J. Gillies, Eugene A Mash

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15 Scopus citations

Abstract

A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-α-MSH ligands or two low affinity MSH(4) ligands. The linker was incorporated into the conjugate by solid-phase synthesis. In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone.

Original languageEnglish (US)
Pages (from-to)1675-1680
Number of pages6
JournalJournal of Organic Chemistry
Volume72
Issue number5
DOIs
Publication statusPublished - Mar 2 2007

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ASJC Scopus subject areas

  • Organic Chemistry

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