Design, synthesis, and validation of a branched flexible linker for bioactive peptides

Martina E. Bowen, Yasunari Monguchi, Rajesh Sankaranarayanan, Josef Vagner, Lucinda J. Begay, Liping Xu, Bhumasamudram Jagadish, Victor J. Hruby, Robert J. Gillies, Eugene A. Mash

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-α-MSH ligands or two low affinity MSH(4) ligands. The linker was incorporated into the conjugate by solid-phase synthesis. In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone.

Original languageEnglish (US)
Pages (from-to)1675-1680
Number of pages6
JournalJournal of Organic Chemistry
Volume72
Issue number5
DOIs
StatePublished - Mar 2 2007

ASJC Scopus subject areas

  • Organic Chemistry

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    Bowen, M. E., Monguchi, Y., Sankaranarayanan, R., Vagner, J., Begay, L. J., Xu, L., Jagadish, B., Hruby, V. J., Gillies, R. J., & Mash, E. A. (2007). Design, synthesis, and validation of a branched flexible linker for bioactive peptides. Journal of Organic Chemistry, 72(5), 1675-1680. https://doi.org/10.1021/jo062276g