Design, synthesis, and validation of rigid linkers for bioactive peptides

Yasunari Monguchi, Josef Vagner, Heather L. Handl, Umasish Jana, Lucinda J. Begay, Victor J Hruby, Robert J. Gillies, Eugene A Mash

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.

Original languageEnglish (US)
Pages (from-to)7589-7592
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number44
DOIs
Publication statusPublished - Oct 31 2005

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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