Design, synthesis, and validation of rigid linkers for bioactive peptides

Yasunari Monguchi, Josef Vagner, Heather L. Handl, Umasish Jana, Lucinda J. Begay, Victor J Hruby, Robert J. Gillies, Eugene A Mash

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.

Original languageEnglish (US)
Pages (from-to)7589-7592
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number44
DOIs
StatePublished - Oct 31 2005

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Ligands
Peptides
Solid-Phase Synthesis Techniques
4-Nle-7-Phe-alpha-mSH
human MC4R protein

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Design, synthesis, and validation of rigid linkers for bioactive peptides. / Monguchi, Yasunari; Vagner, Josef; Handl, Heather L.; Jana, Umasish; Begay, Lucinda J.; Hruby, Victor J; Gillies, Robert J.; Mash, Eugene A.

In: Tetrahedron Letters, Vol. 46, No. 44, 31.10.2005, p. 7589-7592.

Research output: Contribution to journalArticle

Monguchi, Yasunari ; Vagner, Josef ; Handl, Heather L. ; Jana, Umasish ; Begay, Lucinda J. ; Hruby, Victor J ; Gillies, Robert J. ; Mash, Eugene A. / Design, synthesis, and validation of rigid linkers for bioactive peptides. In: Tetrahedron Letters. 2005 ; Vol. 46, No. 44. pp. 7589-7592.
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