Designing peptide and protein ligands for biological receptors

Victor J. Hruby, Shubh D. Sharma

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A clearer understanding of structure-function relationships of protein hormone-receptor systems is emerging from the increased use of molecular biology approaches. On the other hand, the introduction of rationally designed conformational constraints into peptide hormones and neurotransmitters is leading to the development of highly receptor-selective ligands that allow further investigations into the topographic modulation of their bioactivities and rational design principles for peptide antagonists.

Original languageEnglish (US)
Pages (from-to)599-605
Number of pages7
JournalCurrent Opinion in Biotechnology
Volume2
Issue number4
DOIs
StatePublished - Aug 1991

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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