Detecting molecular recognition with adaptive interferometry

The adaptive-optical BioCD

David D. Nolte, Leilei Peng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a high-speed interferometric optical assay called the BioCD. It is a spinning disk on which antibody molecules are printed that test for specific proteins in biological samples. The class of the BioCD that I will describe here uses adaptive beam combining in a photorefractive quantum well device to establish interferometric phase quadrature between the signal and reference beams. The interferometer is linearly sensitive to small numbers of captured biological molecules and adaptively compensates for mechanical vibrations and wobble in the optical disk.

Original languageEnglish (US)
Title of host publicationOSA Trends in Optics and Photonics Series
PublisherOptical Society of American (OSA)
Pages650-654
Number of pages5
Volume99
StatePublished - 2005
Externally publishedYes
Event10th International Conference on Photorefractive, Effects, Materials, and Devices - Hainan, China
Duration: Jul 19 2005Jul 23 2005

Other

Other10th International Conference on Photorefractive, Effects, Materials, and Devices
CountryChina
CityHainan
Period7/19/057/23/05

Fingerprint

Molecular recognition
Interferometry
Molecules
Antibodies
Interferometers
Semiconductor quantum wells
Assays
Proteins

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Nolte, D. D., & Peng, L. (2005). Detecting molecular recognition with adaptive interferometry: The adaptive-optical BioCD. In OSA Trends in Optics and Photonics Series (Vol. 99, pp. 650-654). Optical Society of American (OSA).

Detecting molecular recognition with adaptive interferometry : The adaptive-optical BioCD. / Nolte, David D.; Peng, Leilei.

OSA Trends in Optics and Photonics Series. Vol. 99 Optical Society of American (OSA), 2005. p. 650-654.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nolte, DD & Peng, L 2005, Detecting molecular recognition with adaptive interferometry: The adaptive-optical BioCD. in OSA Trends in Optics and Photonics Series. vol. 99, Optical Society of American (OSA), pp. 650-654, 10th International Conference on Photorefractive, Effects, Materials, and Devices, Hainan, China, 7/19/05.
Nolte DD, Peng L. Detecting molecular recognition with adaptive interferometry: The adaptive-optical BioCD. In OSA Trends in Optics and Photonics Series. Vol. 99. Optical Society of American (OSA). 2005. p. 650-654
Nolte, David D. ; Peng, Leilei. / Detecting molecular recognition with adaptive interferometry : The adaptive-optical BioCD. OSA Trends in Optics and Photonics Series. Vol. 99 Optical Society of American (OSA), 2005. pp. 650-654
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