Detecting molecular recognition with adaptive interferometry: The adaptive-optical BioCD

David D. Nolte, Leilei Peng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a high-speed interferometric optical assay called the BioCD. It is a spinning disk on which antibody molecules are printed that test for specific proteins in biological samples. The class of the BioCD that I will describe here uses adaptive beam combining in a photorefractive quantum well device to establish interferometric phase quadrature between the signal and reference beams. The interferometer is linearly sensitive to small numbers of captured biological molecules and adaptively compensates for mechanical vibrations and wobble in the optical disk.

Original languageEnglish (US)
Title of host publicationOptics InfoBase Conference Papers
PublisherOptical Society of America
Pages650-654
Number of pages5
ISBN (Print)1557527938, 9781557527936
StatePublished - 2005
Externally publishedYes
EventPhotorefractive Effects, Materials, and Devices, PEMD 2005 - Sanya, China
Duration: Jul 19 2005Jul 19 2005

Other

OtherPhotorefractive Effects, Materials, and Devices, PEMD 2005
CountryChina
CitySanya
Period7/19/057/19/05

Fingerprint

Molecular recognition
Interferometry
interferometry
Molecules
optical disks
antibodies
Antibodies
quadratures
Interferometers
metal spinning
Semiconductor quantum wells
molecules
Assays
interferometers
high speed
quantum wells
proteins
Proteins
vibration

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

Cite this

Nolte, D. D., & Peng, L. (2005). Detecting molecular recognition with adaptive interferometry: The adaptive-optical BioCD. In Optics InfoBase Conference Papers (pp. 650-654). Optical Society of America.

Detecting molecular recognition with adaptive interferometry : The adaptive-optical BioCD. / Nolte, David D.; Peng, Leilei.

Optics InfoBase Conference Papers. Optical Society of America, 2005. p. 650-654.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nolte, DD & Peng, L 2005, Detecting molecular recognition with adaptive interferometry: The adaptive-optical BioCD. in Optics InfoBase Conference Papers. Optical Society of America, pp. 650-654, Photorefractive Effects, Materials, and Devices, PEMD 2005, Sanya, China, 7/19/05.
Nolte DD, Peng L. Detecting molecular recognition with adaptive interferometry: The adaptive-optical BioCD. In Optics InfoBase Conference Papers. Optical Society of America. 2005. p. 650-654
Nolte, David D. ; Peng, Leilei. / Detecting molecular recognition with adaptive interferometry : The adaptive-optical BioCD. Optics InfoBase Conference Papers. Optical Society of America, 2005. pp. 650-654
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