Detection and half-life of bromobenzene-3,4-oxide in blood

S. S. Lau, T. J. Monks, K. E. Greene, J. R. Gillette

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

1. Bromobenzene-3,4-oxide can be detected in venous blood of rats by trapping it as the corresponding 35[S]glutathione conjugates. 2. More bromobenzene-3,4-oxide is detected in venous blood of rats treated with phenobarbital and diethyl maleate than in venous blood of rats treated with phenobarbital alone. 3. The half-life of bromobenzene-3,4-oxide in venous blood was about 13·5 s. 4. Bromobenzene-3,4-oxide may contribute to the extrahepatic covalent binding and presumably the toxicity observed after bromobenzene administration. 5. The present technique may be used to determine in blood, the presence or absence of other reactive metabolites that form glutathione conjugates.

Original languageEnglish (US)
Pages (from-to)539-543
Number of pages5
JournalXenobiotica
Volume14
Issue number7
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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