Detection limits of captured protein on the BioCD

Chad Barden, Ming Zhao, Xuefeng Wang, David D. Nolte

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The BioCD is a spinning biochip that uses quadrature laser interferometry to detect captured protein on the disc surface. We describe the detection limits of protein binding on this optical biosensor. The fundamental metrology limit is 1 picometer for a single 100-micron diameter spot. Under assay conditions for prostate specific antigen, we can detect 25 pg/ml at 10 assays per disc.

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium Proceedings
Pages93-97
Number of pages5
Volume1133
StatePublished - 2008
Externally publishedYes
Event2008 MRS Fall Meeting - Boston, MA, United States
Duration: Dec 1 2008Dec 5 2008

Other

Other2008 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period12/1/0812/5/08

Fingerprint

Assays
Laser interferometry
proteins
Proteins
Biochips
laser interferometry
antigens
Prostate-Specific Antigen
Antigens
bioinstrumentation
Biosensors
quadratures
metal spinning
metrology
Protein Binding

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Barden, C., Zhao, M., Wang, X., & Nolte, D. D. (2008). Detection limits of captured protein on the BioCD. In Materials Research Society Symposium Proceedings (Vol. 1133, pp. 93-97)

Detection limits of captured protein on the BioCD. / Barden, Chad; Zhao, Ming; Wang, Xuefeng; Nolte, David D.

Materials Research Society Symposium Proceedings. Vol. 1133 2008. p. 93-97.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Barden, C, Zhao, M, Wang, X & Nolte, DD 2008, Detection limits of captured protein on the BioCD. in Materials Research Society Symposium Proceedings. vol. 1133, pp. 93-97, 2008 MRS Fall Meeting, Boston, MA, United States, 12/1/08.
Barden C, Zhao M, Wang X, Nolte DD. Detection limits of captured protein on the BioCD. In Materials Research Society Symposium Proceedings. Vol. 1133. 2008. p. 93-97
Barden, Chad ; Zhao, Ming ; Wang, Xuefeng ; Nolte, David D. / Detection limits of captured protein on the BioCD. Materials Research Society Symposium Proceedings. Vol. 1133 2008. pp. 93-97
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