Detection limits of captured protein on the BioCD

Chad Barden, Ming Zhao, Xuefeng Wang, David D. Nolte

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The BioCD is a spinning biochip that uses quadrature laser interferometry to detect captured protein on the disc surface. We describe the detection limits of protein binding on this optical biosensor. The fundamental metrology limit is 1 picometer for a single 100-micron diameter spot. Under assay conditions for prostate specific antigen, we can detect 25 pg/ml at 10 assays per disc.

Original languageEnglish (US)
Title of host publicationMaterials for Optical Sensors in Biomedical Applications
Number of pages5
StatePublished - Dec 1 2008
Event2008 MRS Fall Meeting - Boston, MA, United States
Duration: Dec 1 2008Dec 5 2008

Publication series

NameMaterials Research Society Symposium Proceedings
ISSN (Print)0272-9172


Other2008 MRS Fall Meeting
Country/TerritoryUnited States
CityBoston, MA

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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