Detection of carboxyhemefibrinogen and methemefibrinogen in a patient with thrombosis of a HeartMate II ventricular assist device

M. Cristina Smith, Vance G Nielsen

Research output: Contribution to journalArticle

11 Scopus citations


Ventricular assist device (VAD) thrombosis is a devastating, potentially fatal complication suffered by patients requiring mechanical circulatory support. We present a patient with thrombosis of a HeartMate II VAD with concurrent hemolysis and increased carbon monoxide formation. Using a specialized thrombelastographic assay, we detected marked plasmatic hypercoagulability mediated in part by the formation of carboxyhemefibrinogen.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalASAIO Journal
Issue number1
Publication statusPublished - Jan 2013



  • carbon monoxide
  • fibrinogen
  • thrombelastography
  • thrombosis
  • ventricular assist device

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering
  • Medicine(all)

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