Detection of coccidioidal antibodies by 33-kDa spherule antigen, Coccidioides EIA, and standard serologic tests in sera from patients evaluated for coccidioidomycosis

Marion A. Wieden, Linda L. Lundergan, Jay Blum, Kathy L. Delgado, Rosario Coolbaugh, Ray Howard, Tao Peng, Evelyn Pugh, Norma Reis, Jerry Theis, John N. Galgiani

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

During a 9-month study of patients being evaluated for coccidioidomycosis, 1 or more serum samples were obtained from 138 patients with an illness suggestive of recent infection. In this group, standard immunodiffusion tests of unconcentrated sera were positive for 25; 49 additional patients had at least 1 reactive test result by newer enzyme- linked serologic tests. At least 11 of these 49 patients had coccidioidomycosis as determined by culture or subsequent standard serologic tests. Patients with coccidioidomycosis identified only by newer tests had fewer or milder clinical abnormalities than did patients in whom the disease was detected by standard tests. For 31 other patients with illness of a chronic or undetermined duration, newer tests detected only 10 more than the 18 identified by standard tests, suggesting that later in the course of illness, standard testing gains in sensitivity for coccidioidal infection.

Original languageEnglish (US)
Pages (from-to)1273-1277
Number of pages5
JournalJournal of Infectious Diseases
Volume173
Issue number5
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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