@article{0b99e42406f64650904fb6b8762564f5,
title = "Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent",
abstract = "A responsive magnetic resonance (MRI) contrast agent has been developed that can detect the enzyme activity of DT-diaphorase. The agent produced different chemical exchange saturation transfer (CEST) MRI signals before and after incubation with the enzyme, NADH, and GSH at different pH values whereas it showed good stability in a reducing environment without enzyme.",
keywords = "CEST MRI, NQO1, dt-diaphorase, molecular imaging, trimethyl lock",
author = "Iman Daryaei and Jones, {Kyle M.} and Pagel, {Mark D.}",
note = "Funding Information: The authors would like to thank Dr. Vahe Bandarian and Micah T. Nelp for access to their laboratory instruments and active involvement in setting up enzyme reactions. The authors also thank Dr. Indraneel Ghosh, Dr. Karla Camacho-Soto, and Dr. Luca Ogunleye for access to their laboratory instruments and assistance with HPLC analysis and purifications. This research was supported by the National Institutes of Health (NIH) through grants R01 CA169774 and P01 CA95060. K.M.J. was supported through NIH training grants T32HL007955 and T32HL066988. Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2017",
month = may,
day = "11",
doi = "10.1002/chem.201700721",
language = "English (US)",
volume = "23",
pages = "6514--6517",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "27",
}