Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent

Iman Daryaei, Kyle M. Jones, Mark "Marty" Pagel

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A responsive magnetic resonance (MRI) contrast agent has been developed that can detect the enzyme activity of DT-diaphorase. The agent produced different chemical exchange saturation transfer (CEST) MRI signals before and after incubation with the enzyme, NADH, and GSH at different pH values whereas it showed good stability in a reducing environment without enzyme.

Original languageEnglish (US)
Pages (from-to)6514-6517
Number of pages4
JournalChemistry - A European Journal
Volume23
Issue number27
DOIs
Publication statusPublished - May 11 2017

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Keywords

  • CEST MRI
  • dt-diaphorase
  • molecular imaging
  • NQO1
  • trimethyl lock

ASJC Scopus subject areas

  • Chemistry(all)

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