Detection of picogram levels of sufentanil by capillary gas chromotography

S. T. Weldon, D. F. Perry, R. C. Cork, A Jay Gandolfi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Sufentanil and its two primary metabolites, N-(4-[methoxymethyl]-4-piperidinyl)-N-phenyl propanamide (MPPP), and N-(4[hydroxymethyl]-1-[2-thienylethyl]-4-piperidinyl)-N-phenyl propanamide (desmethyl sufentanil), were detected by capillary gas chromatography with a nitrogen-phosphorous detector. The detection limit for sufentanil and its metabolites is 30-50 pg/ml with minimal interfering substances in the chromatograms. This method allowed for the detection of serum surfentanil in the terminal elimination phase of sufentanil in a patient receiving 1.5 μg/kg and will allow for studies to determine the pharmacokinetics and metabolism of sufentanil in a wide variety of patient groups now receiving this agent.

Original languageEnglish (US)
Pages (from-to)684-687
Number of pages4
JournalAnesthesiology
Volume63
Issue number6
StatePublished - 1985

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Sufentanil
Gases
Gas Chromatography
Limit of Detection
Nitrogen
Pharmacokinetics
Serum

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Detection of picogram levels of sufentanil by capillary gas chromotography. / Weldon, S. T.; Perry, D. F.; Cork, R. C.; Gandolfi, A Jay.

In: Anesthesiology, Vol. 63, No. 6, 1985, p. 684-687.

Research output: Contribution to journalArticle

Weldon, ST, Perry, DF, Cork, RC & Gandolfi, AJ 1985, 'Detection of picogram levels of sufentanil by capillary gas chromotography', Anesthesiology, vol. 63, no. 6, pp. 684-687.
Weldon, S. T. ; Perry, D. F. ; Cork, R. C. ; Gandolfi, A Jay. / Detection of picogram levels of sufentanil by capillary gas chromotography. In: Anesthesiology. 1985 ; Vol. 63, No. 6. pp. 684-687.
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