Detection of picogram levels of sufentanil by capillary gas chromotography

S. T. Weldon, D. F. Perry, R. C. Cork, A Jay Gandolfi

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Abstract

Sufentanil and its two primary metabolites, N-(4-[methoxymethyl]-4-piperidinyl)-N-phenyl propanamide (MPPP), and N-(4[hydroxymethyl]-1-[2-thienylethyl]-4-piperidinyl)-N-phenyl propanamide (desmethyl sufentanil), were detected by capillary gas chromatography with a nitrogen-phosphorous detector. The detection limit for sufentanil and its metabolites is 30-50 pg/ml with minimal interfering substances in the chromatograms. This method allowed for the detection of serum surfentanil in the terminal elimination phase of sufentanil in a patient receiving 1.5 μg/kg and will allow for studies to determine the pharmacokinetics and metabolism of sufentanil in a wide variety of patient groups now receiving this agent.

Original languageEnglish (US)
Pages (from-to)684-687
Number of pages4
JournalAnesthesiology
Volume63
Issue number6
Publication statusPublished - 1985

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ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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