Detection of Positive and Negative Ions from a Flowing Atmospheric Pressure Afterglow Using a Mattauch-Herzog Mass Spectrograph Equipped with a Faraday-Strip Array Detector

Gregory D. Schilling, Jacob T. Shelley, James H. Barnes, Roger P. Sperline, M. Bonner Denton, Charles J. Barinaga, David W. Koppenaal, Gary M. Hieftje

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

An ambient desorption/ionization (ADI) source, known as the flowing atmospheric pressure afterglow (FAPA), has been coupled to a Mattauch-Herzog mass spectrograph (MHMS) equipped with a focal plane camera (FPC) array detector. The FAPA ionization source enables direct mass spectral analysis of solids, liquids, and gases through either positive or negative ionization modes. In either case, spectra are generally simple with dominant peaks being the molecular ions or protonated molecular ions. Use of the FAPA source with the MHMS allows the FPC detector to be characterized for the determination of molecular species, whereas previously only atomic mass spectrometry (MS) has been demonstrated. Furthermore, the FPC is shown to be sensitive to negative ions without the need to change any detector parameters. The analysis of solid, liquid, and gaseous samples through positive and negative ionization is demonstrated with detection limits (1-25 fmol/s, ∼0.3-10 pg of analyte per mL of helium) surpassing those obtained with the FAPA source coupled to a time-of-flight mass analyzer.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalJournal of the American Society for Mass Spectrometry
Volume21
Issue number1
DOIs
StatePublished - Jan 2010

ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy

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