Determination of phosphate functional group acid dissociation constants of clindamycin 2-phosphate using 31P Fourier transform NMR spectrometry

James E. Kipp, Walter J. Smith, Paul B. Myrdal

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

31P-NMR spectrometric titration was used to determine the apparent first and second acid dissociation constants of the phosphate functional group in clindamycin 2-phosphate at 21°C. Using a standard rapid exchange model, values of 0.964 and 6.06 were determined.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume74
Issue number2-3
DOIs
StatePublished - Aug 16 1991

Keywords

  • Acid dissociation
  • Clindamycin phosphate
  • NMR
  • P-NMR
  • pH dependence

ASJC Scopus subject areas

  • Pharmaceutical Science

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