The American Nurses Association has set eight standards of nursing practice related to the nursing process. Computer-aided information systems intended to facilitate the nursing process must be designed to promote adherence to these professional standards. For each of the eight standards, the authors describe how a hypothetical expert system could help nurses meet the standard. A prototype of such an expert system is being developed. Issues in conceptualizing clinical decision-making and developing decision strategies for the prototype system are discussed. The process of developing the prototype system is also described.