Development and testing of a single frequency terahertz imaging system for breast cancer detection

Benjamin St Peter, Sigfrid Yngvesson, Paul Siqueira, Patrick Kelly, Ashraf Khan, Stephen Glick, Andrew Karellas

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The ability to discern malignant from benign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.

Original languageEnglish (US)
Pages (from-to)785-797
Number of pages13
JournalIEEE Journal of Biomedical and Health Informatics
Volume17
Issue number4
DOIs
StatePublished - Oct 14 2013
Externally publishedYes

Fingerprint

Terahertz Imaging
Gas lasers
Laser modes
Imaging systems
Surgery
Terahertz Radiation
Light sources
Conservation
Breast
Systems analysis
Tissue
Breast Neoplasms
Scanning
Radiation
Gas Lasers
Testing
ROC Curve
Technology

Keywords

  • Breast cancer
  • Medical imaging
  • Reflectivity
  • Refractive index
  • Single frequency THz imaging (SFTI)
  • THz

ASJC Scopus subject areas

  • Biotechnology
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Health Information Management

Cite this

Development and testing of a single frequency terahertz imaging system for breast cancer detection. / St Peter, Benjamin; Yngvesson, Sigfrid; Siqueira, Paul; Kelly, Patrick; Khan, Ashraf; Glick, Stephen; Karellas, Andrew.

In: IEEE Journal of Biomedical and Health Informatics, Vol. 17, No. 4, 14.10.2013, p. 785-797.

Research output: Contribution to journalArticle

St Peter, Benjamin ; Yngvesson, Sigfrid ; Siqueira, Paul ; Kelly, Patrick ; Khan, Ashraf ; Glick, Stephen ; Karellas, Andrew. / Development and testing of a single frequency terahertz imaging system for breast cancer detection. In: IEEE Journal of Biomedical and Health Informatics. 2013 ; Vol. 17, No. 4. pp. 785-797.
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