Development and use of a confocal microendoscope for in vivo histopathologic diagnosis

Research output: Contribution to journalConference article

2 Scopus citations

Abstract

A confocal microendoscope for in vivo imaging at the cellular level has been developed. The system consists of a slit-scanning confocal microscope coupled to a fiber optic imaging bundle with a miniature objective lens and focusing mechanism at the distal tip of the catheter. The system is used primarily for imaging tissue fluorescence - either autofluorescence or fluorescence from an exogenous compound. The microendoscope has a lateral resolution of 2 μm allowing visualization of structures at the cellular level, and because it is confocal, it can image at selected depths below the tissue surface. Excellent in vivo imaging results have been obtained in animal models and encouraging ex vivo results have been achieved with human tissue.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4254
DOIs
StatePublished - Jan 1 2001
EventBiomedical Diagnostic, Guidance, and Surgical-Assist Systems III - San Jose, CA, United States
Duration: Jan 21 2001Jan 22 2001

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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