Development and use of a confocal microendoscope for in vivo histopathologic diagnosis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

A confocal microendoscope for in vivo imaging at the cellular level has been developed. The system consists of a slit-scanning confocal microscope coupled to a fiber optic imaging bundle with a miniature objective lens and focusing mechanism at the distal tip of the catheter. The system is used primarily for imaging tissue fluorescence - either autofluorescence or fluorescence from an exogenous compound. The microendoscope has a lateral resolution of 2 μm allowing visualization of structures at the cellular level, and because it is confocal, it can image at selected depths below the tissue surface. Excellent in vivo imaging results have been obtained in animal models and encouraging ex vivo results have been achieved with human tissue.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsT. Vo-Dinh, W.S. Grundfest, D.A. Benaron
Pages41-48
Number of pages8
Volume4254
DOIs
StatePublished - 2001
EventBiomedical Diagnostic, Guidance, and Surgical-Assist Systems III - San Jose, CA, United States
Duration: Jan 21 2001Jan 22 2001

Other

OtherBiomedical Diagnostic, Guidance, and Surgical-Assist Systems III
CountryUnited States
CitySan Jose, CA
Period1/21/011/22/01

Fingerprint

Imaging techniques
Tissue
fluorescence
animal models
Fluorescence
bundles
slits
Catheters
fiber optics
microscopes
lenses
Fiber optics
Lenses
Animals
Microscopes
scanning
Visualization
Scanning

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Gmitro, A. F., & Rouse, A. R. (2001). Development and use of a confocal microendoscope for in vivo histopathologic diagnosis. In T. Vo-Dinh, W. S. Grundfest, & D. A. Benaron (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4254, pp. 41-48) https://doi.org/10.1117/12.427944

Development and use of a confocal microendoscope for in vivo histopathologic diagnosis. / Gmitro, Arthur F; Rouse, Andrew R.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / T. Vo-Dinh; W.S. Grundfest; D.A. Benaron. Vol. 4254 2001. p. 41-48.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gmitro, AF & Rouse, AR 2001, Development and use of a confocal microendoscope for in vivo histopathologic diagnosis. in T Vo-Dinh, WS Grundfest & DA Benaron (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4254, pp. 41-48, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, San Jose, CA, United States, 1/21/01. https://doi.org/10.1117/12.427944
Gmitro AF, Rouse AR. Development and use of a confocal microendoscope for in vivo histopathologic diagnosis. In Vo-Dinh T, Grundfest WS, Benaron DA, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4254. 2001. p. 41-48 https://doi.org/10.1117/12.427944
Gmitro, Arthur F ; Rouse, Andrew R. / Development and use of a confocal microendoscope for in vivo histopathologic diagnosis. Proceedings of SPIE - The International Society for Optical Engineering. editor / T. Vo-Dinh ; W.S. Grundfest ; D.A. Benaron. Vol. 4254 2001. pp. 41-48
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