Abstract
A handheld lab-on-a-chip immunosensor was developed for rapid detection of H1N1/2009 virus inside a 1:10 scale mock classroom. The device detected Mie light scattering from immunoagglutination of antibody-conjugated submicron latex beads with H1N1/2009 target in a handheld optofluidic device. The lowest detectable amount was 55 pg of H1N1/2009 viruses in 0.1 m3 of a room with 2 min sampling time. A 3-D computational fluid dynamics simulation was utilized to track the transport and distribution of H1N1/09 within a mock classroom, and corresponded very well with immunosensor readings. The device and 3-D CFD model could serve as a good model for monitoring the viral pathogen within a human environment.
| Original language | English (US) |
|---|---|
| Title of host publication | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 |
| Pages | 1421-1423 |
| Number of pages | 3 |
| State | Published - Dec 1 2011 |
| Event | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States Duration: Oct 2 2011 → Oct 6 2011 |
Publication series
| Name | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 |
|---|---|
| Volume | 2 |
Other
| Other | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 |
|---|---|
| Country | United States |
| City | Seattle, WA |
| Period | 10/2/11 → 10/6/11 |
Keywords
- Computational fluid dynamics
- Immuagglutination
- Liquid-core waveguide
- Mie scattering
ASJC Scopus subject areas
- Control and Systems Engineering
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Cite this
Kwon, H. J., Angus, S. V., You, D. J., Christopher Stemple, C., & Yoon, J. Y. (2011). Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 1421-1423). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 2).