Abstract
A handheld lab-on-a-chip immunosensor was developed for rapid detection of H1N1/2009 virus inside a 1:10 scale mock classroom. The device detected Mie light scattering from immunoagglutination of antibody-conjugated submicron latex beads with H1N1/2009 target in a handheld optofluidic device. The lowest detectable amount was 55 pg of H1N1/2009 viruses in 0.1 m3 of a room with 2 min sampling time. A 3-D computational fluid dynamics simulation was utilized to track the transport and distribution of H1N1/09 within a mock classroom, and corresponded very well with immunosensor readings. The device and 3-D CFD model could serve as a good model for monitoring the viral pathogen within a human environment.
| Original language | English (US) |
|---|---|
| Title of host publication | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 |
| Pages | 1421-1423 |
| Number of pages | 3 |
| Volume | 2 |
| State | Published - 2011 |
| Event | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States Duration: Oct 2 2011 → Oct 6 2011 |
Other
| Other | 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 |
|---|---|
| Country | United States |
| City | Seattle, WA |
| Period | 10/2/11 → 10/6/11 |
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Keywords
- Computational fluid dynamics
- Immuagglutination
- Liquid-core waveguide
- Mie scattering
ASJC Scopus subject areas
- Control and Systems Engineering
Cite this
Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom. / Kwon, Hyuck Jin; Angus, Scott V.; You, David J.; Christopher Stemple, C.; Yoon, Jeong-Yeol.
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 2 2011. p. 1421-1423.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom
AU - Kwon, Hyuck Jin
AU - Angus, Scott V.
AU - You, David J.
AU - Christopher Stemple, C.
AU - Yoon, Jeong-Yeol
PY - 2011
Y1 - 2011
N2 - A handheld lab-on-a-chip immunosensor was developed for rapid detection of H1N1/2009 virus inside a 1:10 scale mock classroom. The device detected Mie light scattering from immunoagglutination of antibody-conjugated submicron latex beads with H1N1/2009 target in a handheld optofluidic device. The lowest detectable amount was 55 pg of H1N1/2009 viruses in 0.1 m3 of a room with 2 min sampling time. A 3-D computational fluid dynamics simulation was utilized to track the transport and distribution of H1N1/09 within a mock classroom, and corresponded very well with immunosensor readings. The device and 3-D CFD model could serve as a good model for monitoring the viral pathogen within a human environment.
AB - A handheld lab-on-a-chip immunosensor was developed for rapid detection of H1N1/2009 virus inside a 1:10 scale mock classroom. The device detected Mie light scattering from immunoagglutination of antibody-conjugated submicron latex beads with H1N1/2009 target in a handheld optofluidic device. The lowest detectable amount was 55 pg of H1N1/2009 viruses in 0.1 m3 of a room with 2 min sampling time. A 3-D computational fluid dynamics simulation was utilized to track the transport and distribution of H1N1/09 within a mock classroom, and corresponded very well with immunosensor readings. The device and 3-D CFD model could serve as a good model for monitoring the viral pathogen within a human environment.
KW - Computational fluid dynamics
KW - Immuagglutination
KW - Liquid-core waveguide
KW - Mie scattering
UR - http://www.scopus.com/inward/record.url?scp=84883817793&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883817793&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84883817793
SN - 9781618395955
VL - 2
SP - 1421
EP - 1423
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
ER -