Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom

Hyuck Jin Kwon, Scott V. Angus, David J. You, C. Christopher Stemple, Jeong-Yeol Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A handheld lab-on-a-chip immunosensor was developed for rapid detection of H1N1/2009 virus inside a 1:10 scale mock classroom. The device detected Mie light scattering from immunoagglutination of antibody-conjugated submicron latex beads with H1N1/2009 target in a handheld optofluidic device. The lowest detectable amount was 55 pg of H1N1/2009 viruses in 0.1 m3 of a room with 2 min sampling time. A 3-D computational fluid dynamics simulation was utilized to track the transport and distribution of H1N1/09 within a mock classroom, and corresponded very well with immunosensor readings. The device and 3-D CFD model could serve as a good model for monitoring the viral pathogen within a human environment.

Original languageEnglish (US)
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1421-1423
Number of pages3
Volume2
StatePublished - 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

Fingerprint

Immunosensors
Viruses
Computational fluid dynamics
Lab-on-a-chip
Pathogens
Latexes
Antibodies
Light scattering
Sampling
Monitoring
Computer simulation

Keywords

  • Computational fluid dynamics
  • Immuagglutination
  • Liquid-core waveguide
  • Mie scattering

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Kwon, H. J., Angus, S. V., You, D. J., Christopher Stemple, C., & Yoon, J-Y. (2011). Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (Vol. 2, pp. 1421-1423)

Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom. / Kwon, Hyuck Jin; Angus, Scott V.; You, David J.; Christopher Stemple, C.; Yoon, Jeong-Yeol.

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 2 2011. p. 1421-1423.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kwon, HJ, Angus, SV, You, DJ, Christopher Stemple, C & Yoon, J-Y 2011, Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. vol. 2, pp. 1421-1423, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, Seattle, WA, United States, 10/2/11.
Kwon HJ, Angus SV, You DJ, Christopher Stemple C, Yoon J-Y. Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 2. 2011. p. 1421-1423
Kwon, Hyuck Jin ; Angus, Scott V. ; You, David J. ; Christopher Stemple, C. ; Yoon, Jeong-Yeol. / Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 2 2011. pp. 1421-1423
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