Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom

Hyuck Jin Kwon, Scott V. Angus, David J. You, C. Christopher Stemple, Jeong Yeol Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A handheld lab-on-a-chip immunosensor was developed for rapid detection of H1N1/2009 virus inside a 1:10 scale mock classroom. The device detected Mie light scattering from immunoagglutination of antibody-conjugated submicron latex beads with H1N1/2009 target in a handheld optofluidic device. The lowest detectable amount was 55 pg of H1N1/2009 viruses in 0.1 m3 of a room with 2 min sampling time. A 3-D computational fluid dynamics simulation was utilized to track the transport and distribution of H1N1/09 within a mock classroom, and corresponded very well with immunosensor readings. The device and 3-D CFD model could serve as a good model for monitoring the viral pathogen within a human environment.

Original languageEnglish (US)
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1421-1423
Number of pages3
StatePublished - Dec 1 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume2

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

Keywords

  • Computational fluid dynamics
  • Immuagglutination
  • Liquid-core waveguide
  • Mie scattering

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Kwon, H. J., Angus, S. V., You, D. J., Christopher Stemple, C., & Yoon, J. Y. (2011). Development of a handheld optofluidic immunosensor to track the transport and distribution of H1N1/2009 virus in a mock classroom. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 1421-1423). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 2).