Development of a microfluidic-based model of a human prostate gland

Linan Jiang, Fernando Ivich, Meagan Tran, Sander B. Frank, Cindy K. Miranti, Yitshak Zohar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The prostate is a gland at the bladder base of males comprising a pseudo-stratified epithelium surrounded by a fibromuscular stroma, and androgens (AR) are widely recognized to regulate prostate development via signaling between the epithelium and smooth muscles. Since it is difficult to establish a co-culture tissue in petri dishes, we report here for the first time a microfluidic-based system developed for co-cultivation of human prostate epithelium and stroma to recapitulate the functions of a human prostate gland in vivo.

Original languageEnglish (US)
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1625-1627
Number of pages3
ISBN (Electronic)9781510897571
Publication statusPublished - Jan 1 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: Nov 11 2018Nov 15 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume3

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1811/15/18

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Keywords

  • Epithelial cells
  • Human prostate gland
  • Microfluidics
  • Stromal cells

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

Cite this

Jiang, L., Ivich, F., Tran, M., Frank, S. B., Miranti, C. K., & Zohar, Y. (2018). Development of a microfluidic-based model of a human prostate gland. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 1625-1627). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 3). Chemical and Biological Microsystems Society.