Development of an intravenous formulation for the antiviral drug 9-(β-D-arabinofuranosyl)-adenine

S. D. Patel, S. H. Yalkowsky

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

An analytical procedure for the analysis of 9-(β-D-arabinofuranosyl)-adenine (ara-A) was developed and used to determine its solubility as well as stability. A reversed-phase high performance liquid chromatographic method was used to quantitate intact drug and to determine its degradation products in aqueous solutions. The solubility of ara-A was determined in different cosolvent-water mixtures as well as in different pH-buffers. The aqueous solubility of ara-A increased exponentially with a linear increase in the volume fraction of the cosolvent. Stability studies indicate that ara-A is relatively stable in dimethylsulfoxide, dimethylacetamide, and dimethylformamide. In vitro precipitation was studied to evaluate the relative potential for precipitation of the drug on injection. Based on these findings, ara-A may be dissolved in the 70% dimethylsulfoxide-water mixture at 15 mg/ml and injected at a rate of 2 ml/min.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalJournal of Parenteral Science and Technology
Volume41
Issue number1
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Development of an intravenous formulation for the antiviral drug 9-(β-D-arabinofuranosyl)-adenine'. Together they form a unique fingerprint.

  • Cite this