Abstract
Although much effort has been devoted to opioid research since the identification of enkephalins, understanding of the physiological importance and mechanisms of action of endogenous opioids lags behind understanding of opiate alkaloids such as morphine. In recent years, several novel approaches have been refined with promise for the successful development of the long-awaited nonaddicting analgesics that act at the opioid delta receptor. The present communication reviews these efforts.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Pharmaceutical Research |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1991 |
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Keywords
- Delta opioid peptides
- Drug development Peptide drugs
- Nonaddicting analgesics
ASJC Scopus subject areas
- Chemistry(all)
- Pharmaceutical Science
- Pharmacology
Cite this
Development of delta opioid peptides as nonaddicting analgesics. / Rapaka, R. S.; Porreca, Frank.
In: Pharmaceutical Research, Vol. 8, No. 1, 1991, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of delta opioid peptides as nonaddicting analgesics
AU - Rapaka, R. S.
AU - Porreca, Frank
PY - 1991
Y1 - 1991
N2 - Although much effort has been devoted to opioid research since the identification of enkephalins, understanding of the physiological importance and mechanisms of action of endogenous opioids lags behind understanding of opiate alkaloids such as morphine. In recent years, several novel approaches have been refined with promise for the successful development of the long-awaited nonaddicting analgesics that act at the opioid delta receptor. The present communication reviews these efforts.
AB - Although much effort has been devoted to opioid research since the identification of enkephalins, understanding of the physiological importance and mechanisms of action of endogenous opioids lags behind understanding of opiate alkaloids such as morphine. In recent years, several novel approaches have been refined with promise for the successful development of the long-awaited nonaddicting analgesics that act at the opioid delta receptor. The present communication reviews these efforts.
KW - Delta opioid peptides
KW - Drug development Peptide drugs
KW - Nonaddicting analgesics
UR - http://www.scopus.com/inward/record.url?scp=0025960130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025960130&partnerID=8YFLogxK
U2 - 10.1023/A:1015809702296
DO - 10.1023/A:1015809702296
M3 - Article
C2 - 1849640
AN - SCOPUS:0025960130
VL - 8
SP - 1
EP - 8
JO - Pharmaceutical Research
JF - Pharmaceutical Research
SN - 0724-8741
IS - 1
ER -