Development of diabetes mellitus in living pancreas donors and recipients

Rainer W G Gruessner, Alberto Pugliese, Helena K. Reijonen, Stephan Gruessner, Tun Jie, Chirag Desai, David Er Sutherland, George W. Burke

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Previously, recurrence of insulin-dependent diabetes mellitus after pancreas transplants was only sporadically reported. Newer data, however, indicate recurrence rates as high as 5%. After identical-twin pancreas transplants, diabetes recurs in the absence of immunosuppressive therapy - strong evidence that it is an autoimmune disease. After deceased donor pancreas transplants, immunologic markers (autoantibodies, autoreactive T cells) herald recurrence. Selective destruction of β cells, still relatively uncommon, is not restricted to MHC compatibility. The development of diabetes in living pancreas donors is rare; it can be largely avoided by meticulous metabolic evaluation before donation and prevention of obesity after donation.

Original languageEnglish (US)
Pages (from-to)543-551
Number of pages9
JournalExpert Review of Clinical Immunology
Volume7
Issue number4
DOIs
StatePublished - Jul 2011

Fingerprint

Living Donors
Pancreas
Diabetes Mellitus
Transplants
Recurrence
Monozygotic Twins
Immunosuppressive Agents
Type 1 Diabetes Mellitus
Autoantibodies
Autoimmune Diseases
Obesity
Biomarkers
Tissue Donors
T-Lymphocytes
Therapeutics

Keywords

  • diabetes mellitus
  • GAD-65
  • IA-2
  • islet cells
  • living donor
  • pancreas transplant
  • post-transplant recurrence
  • twin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Development of diabetes mellitus in living pancreas donors and recipients. / Gruessner, Rainer W G; Pugliese, Alberto; Reijonen, Helena K.; Gruessner, Stephan; Jie, Tun; Desai, Chirag; Sutherland, David Er; Burke, George W.

In: Expert Review of Clinical Immunology, Vol. 7, No. 4, 07.2011, p. 543-551.

Research output: Contribution to journalArticle

Gruessner, RWG, Pugliese, A, Reijonen, HK, Gruessner, S, Jie, T, Desai, C, Sutherland, DE & Burke, GW 2011, 'Development of diabetes mellitus in living pancreas donors and recipients', Expert Review of Clinical Immunology, vol. 7, no. 4, pp. 543-551. https://doi.org/10.1586/eci.11.19
Gruessner, Rainer W G ; Pugliese, Alberto ; Reijonen, Helena K. ; Gruessner, Stephan ; Jie, Tun ; Desai, Chirag ; Sutherland, David Er ; Burke, George W. / Development of diabetes mellitus in living pancreas donors and recipients. In: Expert Review of Clinical Immunology. 2011 ; Vol. 7, No. 4. pp. 543-551.
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