Development of diabetes mellitus in living pancreas donors and recipients

Rainer Wg Gruessner, Alberto Pugliese, Helena K. Reijonen, Stephan Gruessner, Tun Jie, Chirag Desai, David Er Sutherland, George W. Burke

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Previously, recurrence of insulin-dependent diabetes mellitus after pancreas transplants was only sporadically reported. Newer data, however, indicate recurrence rates as high as 5%. After identical-twin pancreas transplants, diabetes recurs in the absence of immunosuppressive therapy - strong evidence that it is an autoimmune disease. After deceased donor pancreas transplants, immunologic markers (autoantibodies, autoreactive T cells) herald recurrence. Selective destruction of β cells, still relatively uncommon, is not restricted to MHC compatibility. The development of diabetes in living pancreas donors is rare; it can be largely avoided by meticulous metabolic evaluation before donation and prevention of obesity after donation.

Original languageEnglish (US)
Pages (from-to)543-551
Number of pages9
JournalExpert Review of Clinical Immunology
Volume7
Issue number4
DOIs
StatePublished - Jul 1 2011

Keywords

  • GAD-65
  • IA-2
  • diabetes mellitus
  • islet cells
  • living donor
  • pancreas transplant
  • post-transplant recurrence
  • twin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Gruessner, R. W., Pugliese, A., Reijonen, H. K., Gruessner, S., Jie, T., Desai, C., Sutherland, D. E., & Burke, G. W. (2011). Development of diabetes mellitus in living pancreas donors and recipients. Expert Review of Clinical Immunology, 7(4), 543-551. https://doi.org/10.1586/eci.11.19