Development of diabetes mellitus in living pancreas donors and recipients

Rainer W G Gruessner, Alberto Pugliese, Helena K. Reijonen, Stephan Gruessner, Tun Jie, Chirag Desai, David Er Sutherland, George W. Burke

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Previously, recurrence of insulin-dependent diabetes mellitus after pancreas transplants was only sporadically reported. Newer data, however, indicate recurrence rates as high as 5%. After identical-twin pancreas transplants, diabetes recurs in the absence of immunosuppressive therapy - strong evidence that it is an autoimmune disease. After deceased donor pancreas transplants, immunologic markers (autoantibodies, autoreactive T cells) herald recurrence. Selective destruction of β cells, still relatively uncommon, is not restricted to MHC compatibility. The development of diabetes in living pancreas donors is rare; it can be largely avoided by meticulous metabolic evaluation before donation and prevention of obesity after donation.

Original languageEnglish (US)
Pages (from-to)543-551
Number of pages9
JournalExpert Review of Clinical Immunology
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 2011

    Fingerprint

Keywords

  • diabetes mellitus
  • GAD-65
  • IA-2
  • islet cells
  • living donor
  • pancreas transplant
  • post-transplant recurrence
  • twin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this