Experimental exercises have been developed for undergraduate and graduate chemistry, astronomy, biology, and biochemistry students to teach basic principles in physical chemistry using the interstellar medium as the laboratory. Employing a radio telescope, in this case the Arizona Radio Observatory (ARO) 12m antenna, the physical and chemical properties of interstellar gas are investigated by measuring spectra of molecules such as HCO+, HCN, HC3N, CH3CN, and SiO in astronomical sources. For example, laboratory exercises have been created for graduate students with life sciences backgrounds that investigate the nature of organic chemistry in interstellar clouds. Additional laboratories are being developed to teach astronomy graduate and undergraduate students about practical aspects of molecular astrophysics and spectroscopy. Basic chemical principles are thus illustrated through an interesting, non-traditional approach.