TY - JOUR
T1 - Development of leukemia after doxorubicin and cisplatin treatment for ovarian cancer
AU - Chambers, S. K.
AU - Chopyk, R. L.
AU - Chambers, J. T.
AU - Schwartz, P. E.
AU - Duffy, T. P.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1989/12/15
Y1 - 1989/12/15
N2 - Alkylating agents have been the major group of chemotherapeutic agents associated with an increased incidence of secondary leukemias. In ovarian cancer alkylating agents have resulted in a lesser, although still increased, risk of secondary malignancies. This paper reports two cases of ovarian cancer treated with cisplatin and doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH), and the subsequent development of an acute nonlymphocytic leukemia and a preleukemia syndrome. This regimen does not contain alkylating agents, and has not been associated with leukemia in patients with ovarian cancer. In these two cases, abnormalities of chromosomes 5, 7, 11, and 17 are reported which have been shown to occur in therapy‐related leukemia. Cancer 64:2459–2461, 1989.
AB - Alkylating agents have been the major group of chemotherapeutic agents associated with an increased incidence of secondary leukemias. In ovarian cancer alkylating agents have resulted in a lesser, although still increased, risk of secondary malignancies. This paper reports two cases of ovarian cancer treated with cisplatin and doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH), and the subsequent development of an acute nonlymphocytic leukemia and a preleukemia syndrome. This regimen does not contain alkylating agents, and has not been associated with leukemia in patients with ovarian cancer. In these two cases, abnormalities of chromosomes 5, 7, 11, and 17 are reported which have been shown to occur in therapy‐related leukemia. Cancer 64:2459–2461, 1989.
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U2 - 10.1002/1097-0142(19891215)64:12<2459::AID-CNCR2820641210>3.0.CO;2-T
DO - 10.1002/1097-0142(19891215)64:12<2459::AID-CNCR2820641210>3.0.CO;2-T
M3 - Article
C2 - 2819655
AN - SCOPUS:0024827183
VL - 64
SP - 2459
EP - 2461
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 12
ER -