Development of thromboresistant biomaterials. Immobilization of Hirudin onto polymers

Cecilia S.L. Ku, I. Bornstein, J. Breillatt, S. N. Ung-Chhun, R. Johnson, J. Lindon, S. Pokropinski, D. Rimer

Research output: Contribution to conferencePaperpeer-review

2 Scopus citations

Abstract

The authors investigated the feasibility of coating polymers with hirudin to create new thromboresistant biomaterials. In the present study, various surfaces were coated with hirudin and subsequently examined for their effect(s) on the coagulation system and on platelet functions. Results obtained from this investigation suggest that hirudin can be immobilized onto the surface of various polymers for creating new thromboresistant biomaterials. For the maximum efficiency of hirudin-coated surfaces, it is necessary to select proper spacers and attachment sites on hirudin.

Original languageEnglish (US)
Pages44
Number of pages1
StatePublished - 1991
Externally publishedYes
Event17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA
Duration: May 1 1991May 5 1991

Other

Other17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
CityScottsdale, AZ, USA
Period5/1/915/5/91

ASJC Scopus subject areas

  • Materials Science(all)

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