Developmental changes in the connective tissues of the porcine recurrent laryngeal nerve

Ellen O. Campbell, Robin A Samlan, Nathaniel T. Mcmullen, Sarah Cook, Suzette Smiley-Jewell, Julie Barkmeier-Kraemer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The recurrent laryngeal nerve (RLN) branches from the vagus cranial nerve to innervate structures important for voicing and swallowing. Damage to this nerve, commonly associated with surgery or idiopathic etiologies that largely occur with aging, results in impaired voicing and swallowing (Myssiorek, 2004). Sunderland proposed a model of peripheral nerve damage whereby a nerve's ability to resist damage from stretch and compression is determined by the quantity and composition of its epineurial connective tissues (Sunderland, 1951). Thus, it would be expected that epineurium differs depending upon the forces imposed on a nerve within its anatomical setting. The purpose of this study was to investigate RLN epineurium quantity and composition with development. A porcine model (piglet vs. juvenile) was used because of the similarity between porcine and human laryngeal innervation, anatomy and function. The entire RLN was excised bilaterally, and stereological methods were used to quantify the composition of epineurial connective tissues. Compared with the piglet, the juvenile pig RLN was double the diameter. While the piglet had no differences in the percentage of epineurial collagen and adipose between proximal and distal segments of both sides of the RLN, the juvenile pig had a greater percentage of collagen in the proximal segment of both sides of the RLN and a greater percentage of adipose in the distal segment of the left RLN compared with the proximal segment. In addition, unlike the piglet, the juvenile pig had a greater number of fascicles in the proximal than distal segment of the RLN, regardless of nerve side. These findings are consistent with predicted patterns associated with the different anatomical settings of the left and right RLN, show that the RLN changes with age, and support Sunderland's model.

Original languageEnglish (US)
Pages (from-to)625-633
Number of pages9
JournalJournal of Anatomy
Volume222
Issue number6
DOIs
StatePublished - Jun 2013

Fingerprint

Recurrent Laryngeal Nerve
connective tissues
Connective Tissue
nerve tissue
Swine
pig
swine
collagen
damage
Peripheral Nerves
etiology
anatomy
piglets
peripheral nerves
Deglutition
compression
Collagen
tissue
Vagus Nerve
Cranial Nerves

Keywords

  • Epineurium
  • Neuroanatomy
  • Porcine
  • Recurrent laryngeal nerve

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Developmental Biology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Cell Biology

Cite this

Campbell, E. O., Samlan, R. A., Mcmullen, N. T., Cook, S., Smiley-Jewell, S., & Barkmeier-Kraemer, J. (2013). Developmental changes in the connective tissues of the porcine recurrent laryngeal nerve. Journal of Anatomy, 222(6), 625-633. https://doi.org/10.1111/joa.12046

Developmental changes in the connective tissues of the porcine recurrent laryngeal nerve. / Campbell, Ellen O.; Samlan, Robin A; Mcmullen, Nathaniel T.; Cook, Sarah; Smiley-Jewell, Suzette; Barkmeier-Kraemer, Julie.

In: Journal of Anatomy, Vol. 222, No. 6, 06.2013, p. 625-633.

Research output: Contribution to journalArticle

Campbell, EO, Samlan, RA, Mcmullen, NT, Cook, S, Smiley-Jewell, S & Barkmeier-Kraemer, J 2013, 'Developmental changes in the connective tissues of the porcine recurrent laryngeal nerve', Journal of Anatomy, vol. 222, no. 6, pp. 625-633. https://doi.org/10.1111/joa.12046
Campbell EO, Samlan RA, Mcmullen NT, Cook S, Smiley-Jewell S, Barkmeier-Kraemer J. Developmental changes in the connective tissues of the porcine recurrent laryngeal nerve. Journal of Anatomy. 2013 Jun;222(6):625-633. https://doi.org/10.1111/joa.12046
Campbell, Ellen O. ; Samlan, Robin A ; Mcmullen, Nathaniel T. ; Cook, Sarah ; Smiley-Jewell, Suzette ; Barkmeier-Kraemer, Julie. / Developmental changes in the connective tissues of the porcine recurrent laryngeal nerve. In: Journal of Anatomy. 2013 ; Vol. 222, No. 6. pp. 625-633.
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