Developmental differences in acute nigrostriatal and mesocorticolimbic system response to haloperidol

Martin H. Teicher, Natacha I. Barber, Harris A. Gelbard, Amelia L. Gallitano, Alexander Campbell, Elda Marsh, Ross J. Baldessarini

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Dose-dependent effects of haloperidol (2.66 nmol/kg to 79.8 mmol/kg, IP) on levels of dopamine, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were assessed in the corpus striatum, nucleus accumbens, and medial prefrontal cortex (PFCTX) of 18-, 30-, and 110-day-old rats. Eighteen-day-old rats were 35% and 63% more sensitive than adults to the effects of haloperidol on striatal and accumbens turnover and had steeper dose-response cuwes. The dose-response function in the PFCTX was similar to striatum at 18 days, but became shallower and nonsigmoidal with age. Maximally effective doses of haloperidol produced, at all ages, a comparable percent rise in DOPAC levels in all regions. With maturation, the percent rise in HVA progressively outstripped DOPAC response in nucleus accumbens and striatum. Overall, prominent developmental differences emerged in these regions in their sensitivity and response to haloperidol, which are consistent with previously reported differences in behavioral sensitivity.

Original languageEnglish (US)
Pages (from-to)147-156
Number of pages10
JournalNeuropsychopharmacology
Volume9
Issue number2
DOIs
StatePublished - Sep 1993
Externally publishedYes

Keywords

  • Corpus striatum
  • Development
  • Dopamine
  • Haloperidol
  • Nucleus accumbens
  • Prefrontal cortex

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Developmental differences in acute nigrostriatal and mesocorticolimbic system response to haloperidol'. Together they form a unique fingerprint.

  • Cite this

    Teicher, M. H., Barber, N. I., Gelbard, H. A., Gallitano, A. L., Campbell, A., Marsh, E., & Baldessarini, R. J. (1993). Developmental differences in acute nigrostriatal and mesocorticolimbic system response to haloperidol. Neuropsychopharmacology, 9(2), 147-156. https://doi.org/10.1038/npp.1993.53