Developmental expression of glucokinase in rat hypothalamus

Vicki L. Sutherland, Matthew McReynolds, Linda S. Tompkins, Heddwen L. Brooks, Ronald M. Lynch

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Neurons in the hypothalamus sense changes in glucose concentration. Glucokinase (GK), a key enzyme for pancreatic (β)-cell glucose sensing, was found in both the embryonic and adult hypothalamus. GK activity accounted for approximately 20% of total hexokinase (HK) activity in both embryonic and adult hypothalamus with no activity measured in cortical samples, indicating that glucose sensing in the hypothalamus initiates early in development and precedes the maturation of glucose signaling in liver.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalDevelopmental Brain Research
Volume154
Issue number2
DOIs
StatePublished - Feb 8 2005

Keywords

  • Development
  • Glucokinase
  • Glucose sensing
  • RT-PCR

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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