Developmental expression of glucokinase in rat hypothalamus

Vicki L. Sutherland, Matthew McReynolds, Linda S. Tompkins, Heddwen L Brooks, Ron Lynch

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Neurons in the hypothalamus sense changes in glucose concentration. Glucokinase (GK), a key enzyme for pancreatic (β)-cell glucose sensing, was found in both the embryonic and adult hypothalamus. GK activity accounted for approximately 20% of total hexokinase (HK) activity in both embryonic and adult hypothalamus with no activity measured in cortical samples, indicating that glucose sensing in the hypothalamus initiates early in development and precedes the maturation of glucose signaling in liver.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalDevelopmental Brain Research
Volume154
Issue number2
DOIs
StatePublished - Feb 8 2005

Fingerprint

Glucokinase
Hypothalamus
Glucose
Hexokinase
Neurons
Liver
Enzymes

Keywords

  • Development
  • Glucokinase
  • Glucose sensing
  • RT-PCR

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Developmental expression of glucokinase in rat hypothalamus. / Sutherland, Vicki L.; McReynolds, Matthew; Tompkins, Linda S.; Brooks, Heddwen L; Lynch, Ron.

In: Developmental Brain Research, Vol. 154, No. 2, 08.02.2005, p. 255-258.

Research output: Contribution to journalArticle

Sutherland, Vicki L. ; McReynolds, Matthew ; Tompkins, Linda S. ; Brooks, Heddwen L ; Lynch, Ron. / Developmental expression of glucokinase in rat hypothalamus. In: Developmental Brain Research. 2005 ; Vol. 154, No. 2. pp. 255-258.
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