Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes

E. M. Small, S. A. Vokes, R. J. Garriock, D. Li, Paul A Krieg

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The homeodomain transcription factor Nkx2-1 (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalObstetrics and Gynecology
Volume96
Issue number3
StatePublished - Aug 23 2000

Fingerprint

Xenopus
Prosencephalon
Thyroid Gland
Genes
Diencephalon
Lung
Organism Cloning
Chickens
Transcription Factors

Keywords

  • Diencephalon
  • Esophagus
  • Forebrain
  • Homeobox gene
  • Lung
  • NK-2
  • Nkx2- 4
  • Nkx2-1
  • Organogenesis
  • Thyroid

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Small, E. M., Vokes, S. A., Garriock, R. J., Li, D., & Krieg, P. A. (2000). Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes. Obstetrics and Gynecology, 96(3), 259-262.

Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes. / Small, E. M.; Vokes, S. A.; Garriock, R. J.; Li, D.; Krieg, Paul A.

In: Obstetrics and Gynecology, Vol. 96, No. 3, 23.08.2000, p. 259-262.

Research output: Contribution to journalArticle

Small, EM, Vokes, SA, Garriock, RJ, Li, D & Krieg, PA 2000, 'Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes', Obstetrics and Gynecology, vol. 96, no. 3, pp. 259-262.
Small EM, Vokes SA, Garriock RJ, Li D, Krieg PA. Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes. Obstetrics and Gynecology. 2000 Aug 23;96(3):259-262.
Small, E. M. ; Vokes, S. A. ; Garriock, R. J. ; Li, D. ; Krieg, Paul A. / Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes. In: Obstetrics and Gynecology. 2000 ; Vol. 96, No. 3. pp. 259-262.
@article{c8b05867a19541d7a2cd12fc1a283720,
title = "Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes",
abstract = "The homeodomain transcription factor Nkx2-1 (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon. (C) 2000 Elsevier Science Ireland Ltd.",
keywords = "Diencephalon, Esophagus, Forebrain, Homeobox gene, Lung, NK-2, Nkx2- 4, Nkx2-1, Organogenesis, Thyroid",
author = "Small, {E. M.} and Vokes, {S. A.} and Garriock, {R. J.} and D. Li and Krieg, {Paul A}",
year = "2000",
month = "8",
day = "23",
language = "English (US)",
volume = "96",
pages = "259--262",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes

AU - Small, E. M.

AU - Vokes, S. A.

AU - Garriock, R. J.

AU - Li, D.

AU - Krieg, Paul A

PY - 2000/8/23

Y1 - 2000/8/23

N2 - The homeodomain transcription factor Nkx2-1 (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon. (C) 2000 Elsevier Science Ireland Ltd.

AB - The homeodomain transcription factor Nkx2-1 (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon. (C) 2000 Elsevier Science Ireland Ltd.

KW - Diencephalon

KW - Esophagus

KW - Forebrain

KW - Homeobox gene

KW - Lung

KW - NK-2

KW - Nkx2- 4

KW - Nkx2-1

KW - Organogenesis

KW - Thyroid

UR - http://www.scopus.com/inward/record.url?scp=0034705991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034705991&partnerID=8YFLogxK

M3 - Article

C2 - 10960795

AN - SCOPUS:0034705991

VL - 96

SP - 259

EP - 262

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 3

ER -