Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes

Eric M. Small, Steven A. Vokes, Robert J. Garriock, Dongling Li, Paul A. Krieg

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

The homeodomain transcription factor Nkx2-l (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalMechanisms of Development
Volume96
Issue number2
DOIs
StatePublished - Sep 30 2000

Keywords

  • Diencephalon
  • Esophagus
  • Forebrain
  • Homeobox gene
  • Lung
  • NK-2
  • Nkx2-1
  • Nkx2-4
  • Organogenesis
  • Thyroid

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes'. Together they form a unique fingerprint.

  • Cite this