Dexamethasone as an Antiemetic in Patients Treated with Cisplatin

Matti S. Aapro, David S. Alberts

Research output: Contribution to journalLetterpeer-review

109 Scopus citations

Abstract

To the Editor: Cis-diamminedichloroplatinum II (cisplatin) is an important anticancer agent that causes severe nausea and vomiting in most patients. Commonly used antiemetics have had little effect on the incidence of severity of these side effects, but high-dose steroids may prove to be useful antiemetics.1 2 3 We have treated 26 patients (12 women and 14 men with a mean age of 55 years [range, 28 to 74]) with a variety of cancers (10 gynecologic, five pulmonary, four head and neck, four gastrointestinal, and three genitourinary) who were receiving various drug combinations containing cisplatin in doses of 50 to 75 mg. . .

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume305
Issue number9
DOIs
StatePublished - Aug 27 1981

ASJC Scopus subject areas

  • Medicine(all)

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