Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis

S. M. Lee, E. Lightner, Marlys H Witte, S. Oberfield, L. Levine, M. I. New

Research output: Contribution to journalArticle

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Abstract

A 9 year old Mexican boy presented with severe hypertension, hypokalaemia and features suggesting acute glomerulonephritis. Nephrosclerosis was present on renal biopsy. Aldosterone levels were unresponsive to variations in dietary salt intake and plasma renin activity was suppressed. Following oral dexamethasone therapy (2 mg/day), plasma aldosterone decreased to undetectable levels, serum potassium normalized and plasma renin activity gradually increased. Dexamethasone also restored the normal responsiveness of the renin-aldosterone system to postural stimuli. The patient exhibited a marked response to a single dose of ACTH with a rise in plasma aldosterone. Long-term blood pressure control and normal potassium levels have been achieved with oral prednisone therapy (5 mg/day) for a period of one year. This case of dexamethasone suppressible hyperaldosteronism (DSH) illustrates that the degree of hypertension in this syndrome may produce severe renal microvascular lesions. DSH should be considered in all children who present with low renin hypertension.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalActa Endocrinologica
Volume99
Issue number2
StatePublished - 1982

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Nephrosclerosis
Hyperaldosteronism
Aldosterone
Renin
Dexamethasone
Hypertension
Potassium
Kidney
Hypokalemia
Glomerulonephritis
Prednisone
Adrenocorticotropic Hormone
Salts
Blood Pressure
Biopsy
Therapeutics
Serum

ASJC Scopus subject areas

  • Endocrinology

Cite this

Lee, S. M., Lightner, E., Witte, M. H., Oberfield, S., Levine, L., & New, M. I. (1982). Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis. Acta Endocrinologica, 99(2), 251-255.

Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis. / Lee, S. M.; Lightner, E.; Witte, Marlys H; Oberfield, S.; Levine, L.; New, M. I.

In: Acta Endocrinologica, Vol. 99, No. 2, 1982, p. 251-255.

Research output: Contribution to journalArticle

Lee, SM, Lightner, E, Witte, MH, Oberfield, S, Levine, L & New, MI 1982, 'Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis', Acta Endocrinologica, vol. 99, no. 2, pp. 251-255.
Lee SM, Lightner E, Witte MH, Oberfield S, Levine L, New MI. Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis. Acta Endocrinologica. 1982;99(2):251-255.
Lee, S. M. ; Lightner, E. ; Witte, Marlys H ; Oberfield, S. ; Levine, L. ; New, M. I. / Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis. In: Acta Endocrinologica. 1982 ; Vol. 99, No. 2. pp. 251-255.
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