Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases: A National Heart, Lung, and Blood Institute Workshop

Jane A. Leopold, Steven M. Kawut, Micheala A. Aldred, Stephen L. Archer, Ray L. Benza, Michael R. Bristow, Evan L. Brittain, Naomi Chesler, Frances S. Deman, Serpil C. Erzurum, Mark T. Gladwin, Paul M. Hassoun, Anna R. Hemnes, Tim Lahm, Joao A.C. Lima, Joseph Loscalzo, Bradley A. Maron, Laura Mercer Rosa, John H. Newman, Susan RedlineStuart Rich, Franz Rischard, Lissa Sugeng, W. H.Wilson Tang, Ryan J. Tedford, Emily J. Tsai, Corey E. Ventetuolo, You Yang Zhou, Neil R. Aggarwal, Lei Xiao

Research output: Contribution to journalReview articlepeer-review

Abstract

Right ventricular dysfunction is a hallmark of advanced pulmonary vascular, lung parenchymal, and left heart disease, yet the underlying mechanisms that govern (mal)adaptation remain incompletely characterized. Owing to the knowledge gaps in our understanding of the right ventricle (RV) in health and disease, the National Heart, Lung, and Blood Institute commissioned a working group to identify current challenges in the field. These included a need to define and standardize normal RV structure and function in populations; access to RV tissue for research purposes and the development of complex experimental platforms that recapitulate the in vivo environment; and the advancement of imaging and invasive methodologies to study the RV within basic, translational, and clinical research programs. Specific recommendations were provided, including a call to incorporate precision medicine and innovations in prognosis, diagnosis, and novel RV therapeutics for patients with pulmonary vascular disease.

Original languageEnglish (US)
Article numbere007975
Pages (from-to)725-733
Number of pages9
JournalCirculation: Heart Failure
DOIs
StateAccepted/In press - 2021

Keywords

  • cardiovascular disease
  • hemodynamics
  • morbidity
  • prognosis
  • vascular diseases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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