Diagnosisof B cell lymphoma by analysis of immunoglobulin gene rearrangements in biopsy specimens obtained by fine needle aspiration

E. Hu, S. Horning, S. Flynn

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Histologic diagnosis of lymphoma is far more difficult in the disaggregated cells obtained by percutaneous aspiration of lymph nodes than in tissue sections prepared from excisional biopsy specimens. However, the simplicity, economy, and safety of aspiration biopsy makes this an attractive diagnostic option in certain situations. In the present study, we demonstrate that lymph node aspirates provide material that is both suitable and sufficient for accurately detecting clonal proliferations of B cells by analysis of immunoglobulin gene rearrangements. The rearrangements detected in aspirated tissue serve as clonal markers that can be directly compared with the rearrangements found in histologically confirmed lymphoma recovered by open biopsy. The application of gene rearrangements to aspirated material therefore offers a useful method of diagnosing lymphoma, particularly for the purposes of more thorough staging at initial presentation or the evaluation of tissues for possible relapse.

Original languageEnglish (US)
Pages (from-to)278-283
Number of pages6
JournalJournal of Clinical Oncology
Volume4
Issue number3
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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