Diagnostic blood flow monitoring during therapeutic interventions using color Doppler optical coherence tomography

Siavash Yazdanfar, Manish D. Kulkarni, Richard C.K. Wong, Michael V. Sivak, Joseph Willis, Jennifer K. Barton, Ashley J. Welch, Joseph A. Izatt

Research output: Contribution to journalConference article

1 Scopus citations

Abstract

A recently developed modality for blood flow measurement holds high promise in the management of bleeding ulcers. Color Doppler optical coherence tomography (CDOCT) uses low-coherence interferometry and digital signal processing to obtain precise localization of tissue microstructure simultaneous with bi-directional quantitation of blood flow. We discuss CDOCT as a diagnostic tool in the management of bleeding gastrointestinal lesions. Common treatments for bleeding ulcers include local injection of a vasoconstrictor, coagulation of blood via thermal contact or laser treatment, and necrosis of surrounding tissue with a sclerosant. We implemented these procedures in a rat dorsal skin flap model, and acquired CDOCT images before and after treatment. In these studies, CDOCT succeeded in identifying cessation of flow before it could be determined visually. Hence, we demonstrate the diagnostic capabilities of CDOCT in the regulation of bleeding in micron-scale vessels.

Original languageEnglish (US)
Pages (from-to)126-132
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3251
DOIs
StatePublished - Dec 1 1998
Externally publishedYes
EventCoherence Domain Optical Methods in Biomedical Science and Clinical Applications II - San Jose, CA, United States
Duration: Jan 27 1998Jan 28 1998

Keywords

  • Bleeding peptic ulcers
  • Color Doppler optical coherence tomography (CDOCT)
  • Endoscopic treatments
  • High-risk stigmata

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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