Diagnostic value of ascitic fluid lactic dehydrogenase, protein, and WBC levels

Thomas D Boyer, A. M. Kahn, T. B. Reynolds

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Three characteristics of an exudate, i.e., an ascitic fluid lactic dehydrogenase (LDH) level of > 400 Sigma units (SU), an ascitic fluid-serum LDH ratio of > 0.6, and an ascitic fluid-serum protein ratio of > 0.5, were studied in a prospective fashion to determine their usefulness in the differential diagnosis of ascites. The ascitic fluid LDH level did not exceed 400 SU in any patient with uncomplicated chronic liver disease, whereas in patients with malignant, tuberculous, or pancreatic ascites it exceeded 500 SU in 12/19 patients. The finding of two of the three characteristics indicated a nonhepatic cause for the ascites whereas the absence of all three strongly suggested uncomplicated liver disease as the sole cause. The ascitic fluid WBC count was also useful in that values exceeded 500/cu mm in bacterial and tuberculous peritonitis whereas it was low (297 ± 49/cu mm) in chronic liver disease.

Original languageEnglish (US)
Pages (from-to)1103-1105
Number of pages3
JournalArchives of Internal Medicine
Volume138
Issue number7
DOIs
StatePublished - 1978
Externally publishedYes

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Ascitic Fluid
Oxidoreductases
Milk
Ascites
Liver Diseases
Proteins
Chronic Disease
Tuberculous Peritonitis
Exudates and Transudates
Blood Proteins
Differential Diagnosis
Serum

ASJC Scopus subject areas

  • Internal Medicine

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Diagnostic value of ascitic fluid lactic dehydrogenase, protein, and WBC levels. / Boyer, Thomas D; Kahn, A. M.; Reynolds, T. B.

In: Archives of Internal Medicine, Vol. 138, No. 7, 1978, p. 1103-1105.

Research output: Contribution to journalArticle

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