Diagnostics of high grade cervical intraepithelial neoplasia with Mueller matrix polarimetry

M. Kupinski, M. Boffety, R. Ossikovski, A. Pierangelo, J. Rehbinder, J. Vizet, F. Goudail, T. Novikova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An enhancement of contrast between healthy and neoplastic zones in Mueller matrix images of excised cervical tissue was demonstrated in our prior work for the visible wavelength range. In this paper we present the statistical analysis of Mueller polarimetric data for the diagnostics of high grade cervical intraepithelial neoplasia. The results of linear and non-linear post-processing compressions of the full Mueller matrix are discussed and compared in terms of diagnostic performance. The final goal of these studies is to estimate and compare the diagnostic usefulness of 16 polarimetric measurements required for the reconstruction of complete Mueller matrix of a sample, while looking for an optimal design of future imaging protocols.

Original languageEnglish (US)
Title of host publicationNovel Biophotonics Techniques and Applications V
EditorsArjen Amelink, Seemantini K. Nadkarni
PublisherSPIE
ISBN (Electronic)9781510628434
DOIs
StatePublished - Jan 1 2019
EventNovel Biophotonics Techniques and Applications V 2019 - Munich, Germany
Duration: Jun 26 2019Jun 27 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11075
ISSN (Print)1605-7422

Conference

ConferenceNovel Biophotonics Techniques and Applications V 2019
CountryGermany
CityMunich
Period6/26/196/27/19

Keywords

  • cervical intraepithelial neoplasia
  • Mueller matrix imaging
  • optical biopsy
  • postprocessing of polarimetric data
  • statistical analysis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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