Diagnostics of high grade cervical intraepithelial neoplasia with Mueller matrix polarimetry

M. Kupinski, M. Boffety, R. Ossikovski, A. Pierangelo, J. Rehbinder, J. Vizet, F. Goudail, T. Novikova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An enhancement of contrast between healthy and neoplastic zones in Mueller matrix images of excised cervical tissue was demonstrated in our prior work for the visible wavelength range. In this paper we present the statistical analysis of Mueller polarimetric data for the diagnostics of high grade cervical intraepithelial neoplasia. The results of linear and non-linear post-processing compressions of the full Mueller matrix are discussed and compared in terms of diagnostic performance. The final goal of these studies is to estimate and compare the diagnostic usefulness of 16 polarimetric measurements required for the reconstruction of complete Mueller matrix of a sample, while looking for an optimal design of future imaging protocols.

Original languageEnglish (US)
Title of host publicationEuropean Conference on Biomedical Optics, ECBO_2019
PublisherOSA - The Optical Society
ISBN (Electronic)9781557528209
DOIs
StatePublished - 2019
EventEuropean Conference on Biomedical Optics, ECBO_2019 - Munich, Netherlands
Duration: Jun 23 2019Jun 25 2019

Publication series

NameOptics InfoBase Conference Papers
VolumePart F142-ECBO 2019

Conference

ConferenceEuropean Conference on Biomedical Optics, ECBO_2019
CountryNetherlands
CityMunich
Period6/23/196/25/19

Keywords

  • Cervical intraepithelial neoplasia
  • Mueller matrix imaging
  • Optical biopsy
  • Post-processing of polarimetric data
  • Statistical analysis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

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