Diastereospecific tandem Michael-like addition / electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids

Guigen Li, Mark A. Jarosinski, Victor J Hruby

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Abstract

A systematic series of key intermediates of unusual β-methyl-amino acids have been synthesized by using a modified Evans auxiliary in an asymmetric Michael-like reaction followed by direct bromination in a one-pot reaction.

Original languageEnglish (US)
Pages (from-to)2561-2564
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number16
DOIs
Publication statusPublished - Apr 16 1993

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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