Diastereospecific tandem Michael-like addition / electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids

Guigen Li, Mark A. Jarosinski, Victor J Hruby

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

A systematic series of key intermediates of unusual β-methyl-amino acids have been synthesized by using a modified Evans auxiliary in an asymmetric Michael-like reaction followed by direct bromination in a one-pot reaction.

Original languageEnglish (US)
Pages (from-to)2561-2564
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number16
DOIs
StatePublished - Apr 16 1993

Fingerprint

Halogenation
Amino Acids

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Diastereospecific tandem Michael-like addition / electrophilic bromination : A one-pot tandem asymmetric synthesis of precursors of unusual amino acids. / Li, Guigen; Jarosinski, Mark A.; Hruby, Victor J.

In: Tetrahedron Letters, Vol. 34, No. 16, 16.04.1993, p. 2561-2564.

Research output: Contribution to journalArticle

@article{d9cebabba439450cafbc2fe9e0345221,
title = "Diastereospecific tandem Michael-like addition / electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids",
abstract = "A systematic series of key intermediates of unusual β-methyl-amino acids have been synthesized by using a modified Evans auxiliary in an asymmetric Michael-like reaction followed by direct bromination in a one-pot reaction.",
author = "Guigen Li and Jarosinski, {Mark A.} and Hruby, {Victor J}",
year = "1993",
month = "4",
day = "16",
doi = "10.1016/S0040-4039(00)77625-8",
language = "English (US)",
volume = "34",
pages = "2561--2564",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "16",

}

TY - JOUR

T1 - Diastereospecific tandem Michael-like addition / electrophilic bromination

T2 - A one-pot tandem asymmetric synthesis of precursors of unusual amino acids

AU - Li, Guigen

AU - Jarosinski, Mark A.

AU - Hruby, Victor J

PY - 1993/4/16

Y1 - 1993/4/16

N2 - A systematic series of key intermediates of unusual β-methyl-amino acids have been synthesized by using a modified Evans auxiliary in an asymmetric Michael-like reaction followed by direct bromination in a one-pot reaction.

AB - A systematic series of key intermediates of unusual β-methyl-amino acids have been synthesized by using a modified Evans auxiliary in an asymmetric Michael-like reaction followed by direct bromination in a one-pot reaction.

UR - http://www.scopus.com/inward/record.url?scp=0027411466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027411466&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)77625-8

DO - 10.1016/S0040-4039(00)77625-8

M3 - Article

AN - SCOPUS:0027411466

VL - 34

SP - 2561

EP - 2564

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 16

ER -