We performed a within-subject comparison of the kinetics of diazepam given to 7 alcoholic subjects during acute alcohol withdrawal and again after detoxification. The initial rapid exponential decline of plasma diazepam concentrations (t 1 2α was more rapid during (0.21 ± 0.03 hr) than after withdrawal (0.44 ± 0.14 hr, p < 0.05). Terminal t 1 2 clearance, and volumes of distribution changed in individual patients, but mean values did not change. Protein binding was less in patients (93.4 ± 2.4 %) than in healthy controls (97.0 ± 1.0, p < 0.05). The effects of alcohol withdrawal on diazepam disposition do not explain the high doses of diazepam commonly required to treat the withdrawal.
ASJC Scopus subject areas
- Pharmacology (medical)