Diazepam kinetics in acute alcohol withdrawal

Susan M. Pond, Michael Phillips, Neal L. Benowitz, Raymond E. Galinsky, Theodore G. Tong, Charles E. Becker

Research output: Contribution to journalArticle

9 Scopus citations


We performed a within-subject comparison of the kinetics of diazepam given to 7 alcoholic subjects during acute alcohol withdrawal and again after detoxification. The initial rapid exponential decline of plasma diazepam concentrations (t 1 2α was more rapid during (0.21 ± 0.03 hr) than after withdrawal (0.44 ± 0.14 hr, p < 0.05). Terminal t 1 2 clearance, and volumes of distribution changed in individual patients, but mean values did not change. Protein binding was less in patients (93.4 ± 2.4 %) than in healthy controls (97.0 ± 1.0, p < 0.05). The effects of alcohol withdrawal on diazepam disposition do not explain the high doses of diazepam commonly required to treat the withdrawal.

Original languageEnglish (US)
Pages (from-to)832-836
Number of pages5
JournalClinical Pharmacology and Therapeutics
Issue number6
StatePublished - Jun 1979
Externally publishedYes


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Pond, S. M., Phillips, M., Benowitz, N. L., Galinsky, R. E., Tong, T. G., & Becker, C. E. (1979). Diazepam kinetics in acute alcohol withdrawal. Clinical Pharmacology and Therapeutics, 25(6), 832-836. https://doi.org/10.1002/cpt1979256832