Diet and biomarkers of oxidative damage in women previously treated for breast cancer

Cynthia Thomson, Anna R. Giuliano, James W. Shaw, Cheryl L. Rock, Cheryl K. Ritenbaugh, Iman A Hakim, Kathryn A. Hollenbach, David S Alberts, John P. Pierce

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This study sought to evaluate the relationship between dietary intake of fat, poly unsaturated fat, saturated fat, arachidonic acid, and selected dietary antioxidants and levels of oxidative damage as measured by urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-epi-prostaglandin F2α (8-iso-PGF2α) in women previously treated for breast cancer. Two hundred two study subjects participating in the Women's Healthy Eating and Living (WHEL) study were included in this ancillary study. Dietary intakes and concentrations of urinary 8-OHdG and 8-iso-PGF2α were measured at baseline and 12 mo in the 179 women included in the analytical cohort. Study subjects demonstrated a significant reduction in dietary total, poly unsaturated, and saturated fat intake and a significant increase in vitamins E and C and β-carotene intake from baseline to 12 mo. Linear mixed-models analysis using baseline and Year 1 data indicated that vitamin E intake was inversely associated with both 8-OHdG and 8-iso-PGF2α. 8-Iso-PGF2α is increased with increased body mass index (BMI) and polyunsaturated fatty acid (PUFA) intake, indicating an increase in lipid peroxidation with greater BMI and higher PUFA intake. 8-OHdG was inversely related to age but positively related to arachidonic acid, indicating an increase in DNA damage with higher intake of arachidonic acid (meat). The results of this nested case-controlled study provide potential mechanisms by which a high fruit and vegetable, low-fat diet might reduce the recurrence rate of or early-stage breast cancer.

Original languageEnglish (US)
Pages (from-to)146-154
Number of pages9
JournalNutrition and Cancer
Volume51
Issue number2
DOIs
StatePublished - 2005

Fingerprint

Dinoprost
arachidonic acid
breast neoplasms
biomarkers
Biomarkers
fat intake
Breast Neoplasms
Diet
Unsaturated Fats
vitamin E
body mass index
Arachidonic Acid
polyunsaturated fatty acids
diet
Unsaturated Fatty Acids
Vitamin E
low fat diet
healthy diet
carotenes
Body Mass Index

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Food Science

Cite this

Diet and biomarkers of oxidative damage in women previously treated for breast cancer. / Thomson, Cynthia; Giuliano, Anna R.; Shaw, James W.; Rock, Cheryl L.; Ritenbaugh, Cheryl K.; Hakim, Iman A; Hollenbach, Kathryn A.; Alberts, David S; Pierce, John P.

In: Nutrition and Cancer, Vol. 51, No. 2, 2005, p. 146-154.

Research output: Contribution to journalArticle

Thomson, C, Giuliano, AR, Shaw, JW, Rock, CL, Ritenbaugh, CK, Hakim, IA, Hollenbach, KA, Alberts, DS & Pierce, JP 2005, 'Diet and biomarkers of oxidative damage in women previously treated for breast cancer', Nutrition and Cancer, vol. 51, no. 2, pp. 146-154. https://doi.org/10.1207/s15327914nc5102_4
Thomson, Cynthia ; Giuliano, Anna R. ; Shaw, James W. ; Rock, Cheryl L. ; Ritenbaugh, Cheryl K. ; Hakim, Iman A ; Hollenbach, Kathryn A. ; Alberts, David S ; Pierce, John P. / Diet and biomarkers of oxidative damage in women previously treated for breast cancer. In: Nutrition and Cancer. 2005 ; Vol. 51, No. 2. pp. 146-154.
@article{ee9b77c2de0a43548e93b11b9704595a,
title = "Diet and biomarkers of oxidative damage in women previously treated for breast cancer",
abstract = "This study sought to evaluate the relationship between dietary intake of fat, poly unsaturated fat, saturated fat, arachidonic acid, and selected dietary antioxidants and levels of oxidative damage as measured by urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-epi-prostaglandin F2α (8-iso-PGF2α) in women previously treated for breast cancer. Two hundred two study subjects participating in the Women's Healthy Eating and Living (WHEL) study were included in this ancillary study. Dietary intakes and concentrations of urinary 8-OHdG and 8-iso-PGF2α were measured at baseline and 12 mo in the 179 women included in the analytical cohort. Study subjects demonstrated a significant reduction in dietary total, poly unsaturated, and saturated fat intake and a significant increase in vitamins E and C and β-carotene intake from baseline to 12 mo. Linear mixed-models analysis using baseline and Year 1 data indicated that vitamin E intake was inversely associated with both 8-OHdG and 8-iso-PGF2α. 8-Iso-PGF2α is increased with increased body mass index (BMI) and polyunsaturated fatty acid (PUFA) intake, indicating an increase in lipid peroxidation with greater BMI and higher PUFA intake. 8-OHdG was inversely related to age but positively related to arachidonic acid, indicating an increase in DNA damage with higher intake of arachidonic acid (meat). The results of this nested case-controlled study provide potential mechanisms by which a high fruit and vegetable, low-fat diet might reduce the recurrence rate of or early-stage breast cancer.",
author = "Cynthia Thomson and Giuliano, {Anna R.} and Shaw, {James W.} and Rock, {Cheryl L.} and Ritenbaugh, {Cheryl K.} and Hakim, {Iman A} and Hollenbach, {Kathryn A.} and Alberts, {David S} and Pierce, {John P.}",
year = "2005",
doi = "10.1207/s15327914nc5102_4",
language = "English (US)",
volume = "51",
pages = "146--154",
journal = "Nutrition and Cancer",
issn = "0163-5581",
publisher = "Routledge",
number = "2",

}

TY - JOUR

T1 - Diet and biomarkers of oxidative damage in women previously treated for breast cancer

AU - Thomson, Cynthia

AU - Giuliano, Anna R.

AU - Shaw, James W.

AU - Rock, Cheryl L.

AU - Ritenbaugh, Cheryl K.

AU - Hakim, Iman A

AU - Hollenbach, Kathryn A.

AU - Alberts, David S

AU - Pierce, John P.

PY - 2005

Y1 - 2005

N2 - This study sought to evaluate the relationship between dietary intake of fat, poly unsaturated fat, saturated fat, arachidonic acid, and selected dietary antioxidants and levels of oxidative damage as measured by urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-epi-prostaglandin F2α (8-iso-PGF2α) in women previously treated for breast cancer. Two hundred two study subjects participating in the Women's Healthy Eating and Living (WHEL) study were included in this ancillary study. Dietary intakes and concentrations of urinary 8-OHdG and 8-iso-PGF2α were measured at baseline and 12 mo in the 179 women included in the analytical cohort. Study subjects demonstrated a significant reduction in dietary total, poly unsaturated, and saturated fat intake and a significant increase in vitamins E and C and β-carotene intake from baseline to 12 mo. Linear mixed-models analysis using baseline and Year 1 data indicated that vitamin E intake was inversely associated with both 8-OHdG and 8-iso-PGF2α. 8-Iso-PGF2α is increased with increased body mass index (BMI) and polyunsaturated fatty acid (PUFA) intake, indicating an increase in lipid peroxidation with greater BMI and higher PUFA intake. 8-OHdG was inversely related to age but positively related to arachidonic acid, indicating an increase in DNA damage with higher intake of arachidonic acid (meat). The results of this nested case-controlled study provide potential mechanisms by which a high fruit and vegetable, low-fat diet might reduce the recurrence rate of or early-stage breast cancer.

AB - This study sought to evaluate the relationship between dietary intake of fat, poly unsaturated fat, saturated fat, arachidonic acid, and selected dietary antioxidants and levels of oxidative damage as measured by urinary levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-epi-prostaglandin F2α (8-iso-PGF2α) in women previously treated for breast cancer. Two hundred two study subjects participating in the Women's Healthy Eating and Living (WHEL) study were included in this ancillary study. Dietary intakes and concentrations of urinary 8-OHdG and 8-iso-PGF2α were measured at baseline and 12 mo in the 179 women included in the analytical cohort. Study subjects demonstrated a significant reduction in dietary total, poly unsaturated, and saturated fat intake and a significant increase in vitamins E and C and β-carotene intake from baseline to 12 mo. Linear mixed-models analysis using baseline and Year 1 data indicated that vitamin E intake was inversely associated with both 8-OHdG and 8-iso-PGF2α. 8-Iso-PGF2α is increased with increased body mass index (BMI) and polyunsaturated fatty acid (PUFA) intake, indicating an increase in lipid peroxidation with greater BMI and higher PUFA intake. 8-OHdG was inversely related to age but positively related to arachidonic acid, indicating an increase in DNA damage with higher intake of arachidonic acid (meat). The results of this nested case-controlled study provide potential mechanisms by which a high fruit and vegetable, low-fat diet might reduce the recurrence rate of or early-stage breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=19544364660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19544364660&partnerID=8YFLogxK

U2 - 10.1207/s15327914nc5102_4

DO - 10.1207/s15327914nc5102_4

M3 - Article

VL - 51

SP - 146

EP - 154

JO - Nutrition and Cancer

JF - Nutrition and Cancer

SN - 0163-5581

IS - 2

ER -